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Mechanoelectrical transduction-related genetic forms of hearing loss

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dc.contributor.author정진세-
dc.date.accessioned2023-05-31T05:50:33Z-
dc.date.available2023-05-31T05:50:33Z-
dc.date.issued2023-04-
dc.identifier.issn2468-8673-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/194281-
dc.description.abstractHair cells of the mammalian cochlea are specialized mechanosensory cells that convert mechanical stimuli into electrical signals to initiate the neuronal responses that lead to the perception of sound. The mechanoelectrical transduction (MET) machinery of cochlear hair cells is a multimeric protein complex that consists of the pore-forming subunits of the MET channel and several essential accessory subunits that are crucial to regulate channel function and render the channel mechanically sensitive. Mutations have been discovered in the genes that encode all known components of the MET machinery. These mutations cause hearing loss with or without vestibular dysfunction. Some mutations also affect other tissues such as the retina. In this brief review, we will summarize gene mutations that affect the MET machinery of hair cells and how the study of the affected genes has illuminated our understanding of the physiological role of the encoded proteins.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfCURRENT OPINION IN PHYSIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMechanoelectrical transduction-related genetic forms of hearing loss-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.googleauthorJinsei Jung-
dc.contributor.googleauthorUlrich Müller-
dc.identifier.doi10.1016/j.cophys.2023.100632-
dc.contributor.localIdA03742-
dc.relation.journalcodeJ04098-
dc.identifier.pmid36936795-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2468867323000020-
dc.subject.keywordauditory-
dc.subject.keyworddeafness-
dc.subject.keywordhair cell-
dc.subject.keywordhearing loss-
dc.subject.keywordmechanotransduction-
dc.contributor.alternativeNameJung, Jinsei-
dc.contributor.affiliatedAuthor정진세-
dc.citation.volume32-
dc.citation.number1-
dc.citation.startPage100632-
dc.identifier.bibliographicCitationCURRENT OPINION IN PHYSIOLOGY, Vol.32(1) : 100632, 2023-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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