Cited 4 times in
Association of T Cell Senescence with Radiation Pneumonitis in Patients with Non-small Cell Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.contributor.author | 윤홍인 | - |
dc.contributor.author | 김창곤 | - |
dc.date.accessioned | 2023-05-31T05:39:43Z | - |
dc.date.available | 2023-05-31T05:39:43Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194246 | - |
dc.description.abstract | Purpose: Associations between immunosenescence and radiation pneumonitis (RP) are largely unknown. We aimed to identify a peripheral blood T cell senescence biomarker to predict RP in patients with non-small cell lung cancer (NSCLC). Methods and Materials: Patients with locally advanced NSCLC who received definitive concurrent chemoradiotherapy (dCRT) were prospectively registered (cohort 1, n=23; cohort 2, n=31). Peripheral blood was collected at baseline, during dCRT, and at 1 month post-dCRT. Patients were dichotomized to grade ≥2 (G2+) RP and grade 0-1 (G0-1) RP. Flow cytometry was performed to assess phenotypes and functional properties of T cell subsets. RP incidence was estimated via competing risk analysis. Results: Five and six patients exhibited G2+ RP following dCRT in cohorts 1 and 2, respectively. Patients with G2+ RP exhibited a more aged T cell pool and higher frequencies of senescent CD57 | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Inc. | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | CD28 Antigens | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms* | - |
dc.subject.MESH | Radiation Pneumonitis* / etiology | - |
dc.subject.MESH | T-Cell Exhaustion | - |
dc.title | Association of T Cell Senescence with Radiation Pneumonitis in Patients with Non-small Cell Lung Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.contributor.googleauthor | Hongryull Pyo | - |
dc.contributor.googleauthor | Hoyoung Lee | - |
dc.contributor.googleauthor | Dongryul Oh | - |
dc.contributor.googleauthor | Jae Myoung Noh | - |
dc.contributor.googleauthor | Yong Chan Ahn | - |
dc.contributor.googleauthor | Chang Gon Kim | - |
dc.contributor.googleauthor | Hong In Yoon | - |
dc.contributor.googleauthor | Jiyun Lee | - |
dc.contributor.googleauthor | Sehhoon Park | - |
dc.contributor.googleauthor | Hyun-Ae Jung | - |
dc.contributor.googleauthor | Jong-Mu Sun | - |
dc.contributor.googleauthor | Se-Hoon Lee | - |
dc.contributor.googleauthor | Jin Seok Ahn | - |
dc.contributor.googleauthor | Keunchil Park | - |
dc.contributor.googleauthor | Bo Mi Ku | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.contributor.googleauthor | Myung-Ju Ahn | - |
dc.identifier.doi | 10.1016/j.ijrobp.2022.07.018 | - |
dc.contributor.localId | A05226 | - |
dc.relation.journalcode | J01157 | - |
dc.identifier.eissn | 1879-355X | - |
dc.identifier.pmid | 35896144 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0360301622007374 | - |
dc.subject.keyword | T cell senescence | - |
dc.subject.keyword | chemoradiotherapy | - |
dc.subject.keyword | non-small cell lung cancer | - |
dc.subject.keyword | peripheral blood | - |
dc.subject.keyword | radiation pneumonitis | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.citation.volume | 115 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 464 | - |
dc.citation.endPage | 475 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.115(2) : 464-475, 2023-02 | - |
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