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비소세포폐암의 새로운 표적치료

DC Field Value Language
dc.contributor.author곽세현-
dc.contributor.author김은영-
dc.contributor.author김치영-
dc.contributor.author이은혜-
dc.contributor.author장윤수-
dc.contributor.author권혜란-
dc.date.accessioned2023-05-31T05:22:14Z-
dc.date.available2023-05-31T05:22:14Z-
dc.date.issued2023-03-
dc.identifier.issn1975-8456-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/194176-
dc.description.abstractBackground: Lung cancer is representative of a high frequency and high mortality disease and ranks at the top in incidence and mortality in Korea, when excluding thyroid cancer. In this manuscript, we focused on current targeted therapies for lung cancer used widely in the medical field. Current Concepts: The majority of patients with lung cancer cannot be treated with surgery only and require chemotherapeutics or radiation therapy. Currently, classical chemotherapeutic agents, targeted agents, and immune checkpoint inhibitors are the most widely used. Recently, the Research and Development of antibody drug conjugates is gaining attention, and this may become a more widely prescribed treatment in the future. Among the available treatment options, targeted therapy is becoming increasingly feasible and widespread for treating inoperable lung cancers, where driver mutations have been identified, and for adjuvant or neoadjuvant therapies. Next-generation sequencing (NGS) improves the ability to identify driver mutations that were previously difficult to detect and can also be performed on blood samples where no cancer tissue is available for testing. This makes it possible to identify therapeutic targets for targeted therapy more rapidly. Discussion and Conclusion: The most common type of lung cancer in Korea is adenocarcinoma, for which a driver mutation has been identified. Newly developed drugs target previously problematic mutations or cancer cell lines that have acquired resistance induced during the treatment process. The survival rate of patients with lung cancer is expected to improve with the development of tailored treatments for targets identified from the NGS data of the patient. This paper will help clinicians understand the current state of targeted therapies for lung cancer treatment.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean-
dc.publisher대한의사협회-
dc.relation.isPartOfJOURNAL OF THE KOREAN MEDICAL ASSOCIATION(대한의사협회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title비소세포폐암의 새로운 표적치료-
dc.title.alternativeNew targeted therapies for non-small cell lung cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthor이은혜-
dc.contributor.googleauthor곽세현-
dc.contributor.googleauthor김치영-
dc.contributor.googleauthor권혜란-
dc.contributor.googleauthor김은영-
dc.contributor.googleauthor장윤수-
dc.identifier.doi10.5124/jkma.2023.66.3.180-
dc.contributor.localIdA06039-
dc.contributor.localIdA00811-
dc.contributor.localIdA04916-
dc.contributor.localIdA03053-
dc.contributor.localIdA03456-
dc.relation.journalcodeJ01833-
dc.identifier.eissn2093-5951-
dc.subject.keywordLung neoplasms-
dc.subject.keywordNon-small-cell lung carcinoma-
dc.subject.keywordTherapeutics-
dc.subject.keywordMolecular targeted therapy-
dc.contributor.alternativeNameKwak, Se Hyun-
dc.contributor.affiliatedAuthor곽세현-
dc.contributor.affiliatedAuthor김은영-
dc.contributor.affiliatedAuthor김치영-
dc.contributor.affiliatedAuthor이은혜-
dc.contributor.affiliatedAuthor장윤수-
dc.citation.volume66-
dc.citation.number3-
dc.citation.startPage180-
dc.citation.endPage190-
dc.identifier.bibliographicCitationJOURNAL OF THE KOREAN MEDICAL ASSOCIATION(대한의사협회지), Vol.66(3) : 180-190, 2023-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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