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MicroRNA super-resolution imaging in blood for Alzheimer's disease
DC Field | Value | Language |
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dc.contributor.author | 김한결 | - |
dc.contributor.author | 박정윤 | - |
dc.contributor.author | 우지원 | - |
dc.contributor.author | 조한나 | - |
dc.date.accessioned | 2023-05-31T05:20:17Z | - |
dc.date.available | 2023-05-31T05:20:17Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194171 | - |
dc.description.abstract | We propose a novel blood biomarker detection method thatuses miRNA super-resolution imaging to enable the early diagnosisof Alzheimer’s disease (AD). Here, we report a singlemoleculedetection method for visualizing disease-specificmiRNA in tissue from an AD mice model, and peripheral bloodmononuclear cells (PBMCs) from AD patients. Using optimizedMagnified Analysis of Proteome (MAPs), we confirmed that fivemiRNAs contribute to neurodegenerative disease in the brainhippocampi of 5XFAD and wild-type mice. We also assessedPBMCs isolated from the whole blood of AD patients and ahealthy control group, and subsequently analyzed those samplesusing miRNA super-resolution imaging. We detected moremiR-200a-3p expression in the cornu ammonis 1 and dentategyrus regions of 3 month-old 5XFAD mice than in wild-typemice. Additionally, miRNA super-resolution imaging of bloodprovides AD diagnosis platform for studying miRNA regulationinside cells at the single molecule level. Our results present apotential liquid biopsy method that could improve the diagnosisof early stage AD and other diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society for Biochemistry and Molecular Biology | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Alzheimer Disease* / diagnostic imaging | - |
dc.subject.MESH | Alzheimer Disease* / genetics | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Hippocampus / diagnostic imaging | - |
dc.subject.MESH | Hippocampus / metabolism | - |
dc.subject.MESH | Leukocytes, Mononuclear / metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | MicroRNAs* / genetics | - |
dc.subject.MESH | MicroRNAs* / metabolism | - |
dc.subject.MESH | Neurodegenerative Diseases* / metabolism | - |
dc.title | MicroRNA super-resolution imaging in blood for Alzheimer's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Mirae Lee | - |
dc.contributor.googleauthor | Jiwon Woo | - |
dc.contributor.googleauthor | Sang Tae Kim | - |
dc.contributor.googleauthor | Minho Moon | - |
dc.contributor.googleauthor | Sang Yun Kim | - |
dc.contributor.googleauthor | Hanna Cho | - |
dc.contributor.googleauthor | Sujin Kim | - |
dc.contributor.googleauthor | Han-Kyeol Kim | - |
dc.contributor.googleauthor | Jeong-Yoon Park | - |
dc.identifier.doi | 10.5483/BMBRep.2022-0151 | - |
dc.contributor.localId | A05235 | - |
dc.contributor.localId | A01650 | - |
dc.contributor.localId | A06262 | - |
dc.contributor.localId | A03920 | - |
dc.relation.journalcode | J00348 | - |
dc.identifier.eissn | 1976-670X | - |
dc.identifier.pmid | 36404596 | - |
dc.contributor.alternativeName | Kim, Han kyeol | - |
dc.contributor.affiliatedAuthor | 김한결 | - |
dc.contributor.affiliatedAuthor | 박정윤 | - |
dc.contributor.affiliatedAuthor | 우지원 | - |
dc.contributor.affiliatedAuthor | 조한나 | - |
dc.citation.volume | 56 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 190 | - |
dc.citation.endPage | 195 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, Vol.56(3) : 190-195, 2023-03 | - |
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