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Long-term clinical outcomes of intestinal Behçet's disease: A 30-year cohort study at a tertiary hospital in South Korea

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dc.contributor.author김태일-
dc.contributor.author박수정-
dc.contributor.author박재준-
dc.contributor.author박지혜-
dc.contributor.author천재희-
dc.date.accessioned2023-04-27T00:47:21Z-
dc.date.available2023-04-27T00:47:21Z-
dc.date.issued2023-03-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/194133-
dc.description.abstractBackground and aim: We aimed to identify the long-term clinical outcomes of and prognostic factors for intestinal Behçet's disease (BD). Methods: A cohort of 780 patients with intestinal BD between 1997 and 2021 was investigated to determine long-term clinical outcomes and prognostic factors at an inflammatory bowel disease clinic at Severance Hospital, Seoul, Korea. Results: During the median follow-up period of 12.7 ± 7.2 years, 5-aminosalicylic acids, corticosteroids, immunomodulators, and anti-tumor necrosis factor-alpha (TNF-α) agents were required in 94.9%, 67.2%, 43.8%, and 14.6% of the patients, respectively. The cumulative rates of anti-TNF-α use were 3.7%, 7.5%, 8.5%, 12.1%, 17.6%, and 24.0%, and those for abdominal surgery were 5.7%, 10.9%, 12.6%, 16.5%, 21.6%, and 28.3%, at 1, 3, 5, 10, 20, and 30 years, respectively, after initial diagnosis of intestinal BD. The cumulative rates of hospitalization were 11.8%, 21.9%, 27.9%, 38.8%, 54.4%, and 74.8%, and those of emergency room visits were 10.0%, 19.8%, 22.7%, 31.6%, 50.0%, and 65.0% at 1, 3, 5, 10, 20, and 30 years. Older age at primary diagnosis, previous appendectomy history, higher disease activity index for intestinal Behçet's disease score, systemic BD, multiple intestinal ulcers, deep intestinal ulcers, higher C-reactive protein, lower hemoglobin, and lower albumin levels were associated with poor prognosis. Married status, higher body mass index, oral ulceration, and arthritis were negatively associated with poor prognosis. Conclusions: Data on the long-term clinical outcomes of intestinal BD and their prognostic factors could guide physicians in patient monitoring and in optimizing individualized treatment.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Scientific Publications-
dc.relation.isPartOfJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBehcet Syndrome* / drug therapy-
dc.subject.MESHCohort Studies-
dc.subject.MESHHumans-
dc.subject.MESHIntestinal Diseases* / diagnosis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTertiary Care Centers-
dc.subject.MESHTumor Necrosis Factor Inhibitors / therapeutic use-
dc.subject.MESHTumor Necrosis Factor-alpha-
dc.subject.MESHUlcer-
dc.titleLong-term clinical outcomes of intestinal Behçet's disease: A 30-year cohort study at a tertiary hospital in South Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJihye Park-
dc.contributor.googleauthorSoo Jung Park-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorJae Hee Cheon-
dc.identifier.doi10.1111/jgh.16056-
dc.contributor.localIdA01079-
dc.contributor.localIdA01539-
dc.contributor.localIdA01636-
dc.contributor.localIdA04575-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid36346041-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/jgh.16056-
dc.subject.keywordBehçet's disease-
dc.subject.keywordclinical outcomes-
dc.subject.keywordintestinal Behçet's disease-
dc.subject.keywordprognostic factors-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.affiliatedAuthor김태일-
dc.contributor.affiliatedAuthor박수정-
dc.contributor.affiliatedAuthor박재준-
dc.contributor.affiliatedAuthor박지혜-
dc.contributor.affiliatedAuthor천재희-
dc.citation.volume38-
dc.citation.number3-
dc.citation.startPage386-
dc.citation.endPage392-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.38(3) : 386-392, 2023-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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