Cited 4 times in
Short-term Blood Pressure Variability and Incident CKD in Patients With Hypertension: Findings From the Cardiovascular and Metabolic Disease Etiology Research Center-High Risk (CMERC-HI) Study
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 서지원 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 이찬주 | - |
dc.contributor.author | 지종현 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 오동환 | - |
dc.date.accessioned | 2023-04-20T08:27:07Z | - |
dc.date.available | 2023-04-20T08:27:07Z | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 0272-6386 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194096 | - |
dc.description.abstract | Rationale & Objective The association between short-term blood pressure variability (BPV) and kidney outcomes is poorly understood. This study evaluated the association between short-term BPV and kidney disease outcomes in people with hypertension. Study Design Prospective observational cohort study. Setting & Participants 1,173 hypertensive participants in the Cardiovascular and Metabolic Disease Etiology Research Center–High Risk (2013-2018) Study with estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2. Exposure Short-term BPV assessed by average real variability (ARV). Outcome Composite kidney disease outcome (30% decline in eGFR from baseline, new occurrence of eGFR <60 mL/min/1.73 m2, or onset of UACR >300 mg/g). Analytical Approach Multivariable Cox regression analyses to evaluate the association between systolic and diastolic BP ARV (SBP-ARV and DBP-ARV) and outcomes. Results During a median follow-up of 5.4 [4.1-6.5] years, 271 events of the composite kidney disease outcome occurred (46.5 per 1,000 person-years). Multivariable Cox analysis revealed that the highest SBP-ARV and DBP-ARV tertiles were associated with a higher risk of the composite kidney disease outcome than the lowest tertiles, independent of the 24-hour SBP or DBP levels (HR, 1.64 [95% CI, 1.16-2.33], and 1.60 [95% CI, 1.15-2.24] for SBP-ARV and DBP-ARV, respectively). These associations were consistent when SBP-ARV and DBP-ARV were treated as continuous variables (HR per 1.0-unit greater SBP-ARV, 1.03 [95% CI, 1.01-1.06]; HR per 1.0-unit greater DBP-ARV, 1.04 [95% CI, 1.01-1.08]). These associations were consistent, irrespective of subgroups (age, sex, 24-hour SBP or DBP, and moderate albuminuria). However, other measures of short-term BPV including SD, coefficient of variation, and dipping patterns were not associated with the composite kidney disease outcome. Limitations Observational study design, the use of single measurement of 24-hour BP, lack of information on changes in antihypertensive medication during the follow-up.Conclusions Short-term BPV is associated with the development of a composite kidney disease outcome in hypertensive patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | W.B. Saunders | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF KIDNEY DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Blood Pressure / physiology | - |
dc.subject.MESH | Blood Pressure Monitoring, Ambulatory | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension* / complications | - |
dc.subject.MESH | Kidney Failure, Chronic* / therapy | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | Short-term Blood Pressure Variability and Incident CKD in Patients With Hypertension: Findings From the Cardiovascular and Metabolic Disease Etiology Research Center-High Risk (CMERC-HI) Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jong Hyun Jhee | - |
dc.contributor.googleauthor | Donghwan Oh | - |
dc.contributor.googleauthor | Jiwon Seo | - |
dc.contributor.googleauthor | Chan Joo Lee | - |
dc.contributor.googleauthor | Min-Yu Chung | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.identifier.doi | 10.1053/j.ajkd.2022.08.017 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A01913 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A03238 | - |
dc.contributor.localId | A03970 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J00089 | - |
dc.identifier.eissn | 1523-6838 | - |
dc.identifier.pmid | 36241008 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0272638622009283 | - |
dc.subject.keyword | Albuminuria | - |
dc.subject.keyword | ambulatory blood pressure monitoring (ABPM) | - |
dc.subject.keyword | average real variability (ARV) | - |
dc.subject.keyword | chronic kidney disease (CKD) | - |
dc.subject.keyword | diastolic blood pressure (DBP) | - |
dc.subject.keyword | dipping status | - |
dc.subject.keyword | hypertension | - |
dc.subject.keyword | incident CKD | - |
dc.subject.keyword | renal function | - |
dc.subject.keyword | short-term blood pressure variability | - |
dc.subject.keyword | systolic blood pressure (SBP) | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 박성하 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 서지원 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 이찬주 | - |
dc.contributor.affiliatedAuthor | 지종현 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 81 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 384 | - |
dc.citation.endPage | 393.e1 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF KIDNEY DISEASES, Vol.81(4) : 384-393.e1, 2023-04 | - |
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