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The Expression of Programmed Death-Ligand 1 on Immune Cells Is Related to a Better Prognosis in Biliary Tract Cancer
DC Field | Value | Language |
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dc.contributor.author | 김소정 | - |
dc.contributor.author | 박승우 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 박은향 | - |
dc.contributor.author | 박정엽 | - |
dc.contributor.author | 박지훈 | - |
dc.contributor.author | 방승민 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 이희승 | - |
dc.contributor.author | 정문재 | - |
dc.contributor.author | 조중현 | - |
dc.date.accessioned | 2023-04-20T08:23:16Z | - |
dc.date.available | 2023-04-20T08:23:16Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194082 | - |
dc.description.abstract | Background/Aims: Programmed death-ligand 1 (PD-L1) expression in tumor cells is associated with a poor biliary tract cancer (BTC) prognosis; tumor-infiltrating immune cells in the tumor microenvironment are associated with a better prognosis. The effect of PD-L1 expression on immune cells on survival is unclear. We investigated the relationship between PD-L1 expression in immune cells and BTC prognosis. Methods: PD-L1 expression was evaluated using an anti-PD-L1 22C3 mouse monoclonal primary antibody, and its relationships with clinical characteristics and prognosis were analyzed using the Cox proportional hazard model to investigate the prognostic performance of PD-L1 in BTC. Results: Among 144 analyzed cases, patients with positive PD-L1 expression in tumor cells and negative PD-L1 expression in immune cells showed poorer overall survival rates than those exhibiting other expressions (tumor cells: hazard ratio [HR]=1.023, p<0.001; immune cells: HR=0.983, p=0.021). PD-L1 expression in tumor cells was an independent predictor of poor overall survival (HR=1.024, p<0.001). In contrast, PD-L1 expression in immune cells was a predictive marker of good prognosis (HR=0.983, p=0.018). Conclusions: PD-L1 expression in immune cells may be used as an independent factor to evaluate the prognosis of patients with BTC. (Gut Liver, Published online December 13, 2022) | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Editorial Office of Gut and Liver | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The Expression of Programmed Death-Ligand 1 on Immune Cells Is Related to a Better Prognosis in Biliary Tract Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung Chan Kwon | - |
dc.contributor.googleauthor | Seungmin Bang | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Ji Hoon Park | - |
dc.contributor.googleauthor | So Jeong Kim | - |
dc.contributor.googleauthor | Jung Hyun Jo | - |
dc.contributor.googleauthor | Moon Jae Chung | - |
dc.contributor.googleauthor | Jeong Youp Park | - |
dc.contributor.googleauthor | Seung Woo Park | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.contributor.googleauthor | Eunhyang Park | - |
dc.contributor.googleauthor | Hee Seung Lee | - |
dc.identifier.doi | 10.5009/gnl220206 | - |
dc.contributor.localId | A06335 | - |
dc.contributor.localId | A01551 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A05760 | - |
dc.contributor.localId | A01647 | - |
dc.contributor.localId | A06415 | - |
dc.contributor.localId | A01786 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03349 | - |
dc.contributor.localId | A03602 | - |
dc.contributor.localId | A03912 | - |
dc.relation.journalcode | J00954 | - |
dc.identifier.eissn | 2005-1212 | - |
dc.identifier.pmid | 36510775 | - |
dc.subject.keyword | Biliary tract neoplsms | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Kim, So Jeong | - |
dc.contributor.affiliatedAuthor | 김소정 | - |
dc.contributor.affiliatedAuthor | 박승우 | - |
dc.contributor.affiliatedAuthor | 박영년 | - |
dc.contributor.affiliatedAuthor | 박은향 | - |
dc.contributor.affiliatedAuthor | 박정엽 | - |
dc.contributor.affiliatedAuthor | 박지훈 | - |
dc.contributor.affiliatedAuthor | 방승민 | - |
dc.contributor.affiliatedAuthor | 송시영 | - |
dc.contributor.affiliatedAuthor | 이희승 | - |
dc.contributor.affiliatedAuthor | 정문재 | - |
dc.contributor.affiliatedAuthor | 조중현 | - |
dc.citation.volume | 17 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | epub. | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, Vol.17(2) : epub., 2023-03 | - |
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