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Effects of Tegoprazan Versus Esomeprazole on Nighttime Heartburn and Sleep Quality in Gastroesophageal Reflux Disease: A Multicenter Double-blind Randomized Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | 이상길 | - |
dc.date.accessioned | 2023-04-20T08:19:59Z | - |
dc.date.available | 2023-04-20T08:19:59Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2093-0879 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194066 | - |
dc.description.abstract | Background/aims: Patients with gastroesophageal reflux disease (GERD) frequently experience nighttime heartburn and sleep disturbance. Tegoprazan is a new potassium-competitive acid blocker that can rapidly block acid secretion. This study aims to evaluate the efficacy of tegoprazan compared with esomeprazole in relieving nighttime heartburn and sleep disturbances. Methods: Patients with erosive esophagitis, nighttime heartburn, and sleep disturbances were randomized to receive tegoprazan 50 mg or esomeprazole 40 mg for 2 weeks. The primary endpoint was time to first nighttime heartburn-free interval. The percentage of nighttime heartburn-free days was also compared between the 2 groups. Results: A total of 46 patients were enrolled in this study. Time to the first nighttime heartburn-free interval was shorter with tegoprazan than with esomeprazole but the difference was not statistically significant (1.5 days vs 3 days, P = 0.151). The percentage of nighttime heartburn-free days was higher in the tegoprazan group but the difference was insignificant (57.8% vs 43.1%, P = 0.107). Adverse events occurred in 2 patients. They were mild in severity. Conclusions: Tegoprazan may induce faster relief of nighttime heartburn symptoms and may improve sleep disorders associated with nighttime heartburn. Further large-scale studies are required to validate our findings. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | Korean Society of Neurogastroenterology and Motility | - |
dc.relation.isPartOf | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Effects of Tegoprazan Versus Esomeprazole on Nighttime Heartburn and Sleep Quality in Gastroesophageal Reflux Disease: A Multicenter Double-blind Randomized Controlled Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Joon Sung Kim | - |
dc.contributor.googleauthor | Seung In Seo | - |
dc.contributor.googleauthor | Sun Hyung Kang | - |
dc.contributor.googleauthor | Sang Kil Lee | - |
dc.contributor.googleauthor | Ah Rong Kim | - |
dc.contributor.googleauthor | Hyun Wook Park | - |
dc.contributor.googleauthor | Bong Tae Kim | - |
dc.contributor.googleauthor | Geun Seog Song | - |
dc.identifier.doi | 10.5056/jnm22104 | - |
dc.contributor.localId | A02812 | - |
dc.relation.journalcode | J01623 | - |
dc.identifier.eissn | 2093-0887 | - |
dc.identifier.pmid | 36581325 | - |
dc.subject.keyword | Gastroesophageal reflux | - |
dc.subject.keyword | Heartburn | - |
dc.subject.keyword | Potassium channel blockers | - |
dc.subject.keyword | Proton pump inhibitors | - |
dc.subject.keyword | Sleep wake disorders | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | 이상길 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 58 | - |
dc.citation.endPage | 64 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, Vol.29(1) : 58-64, 2023-01 | - |
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