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Association of Pre- and Post-Donation Renal Function with Midterm Estimated Glomerular Filtration Rate in Living Kidney Donors: A Retrospective Study
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.contributor.author | 김소연 | - |
dc.contributor.author | 박진하 | - |
dc.contributor.author | 조진선 | - |
dc.contributor.author | 함성연 | - |
dc.date.accessioned | 2023-04-20T08:10:19Z | - |
dc.date.available | 2023-04-20T08:10:19Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194012 | - |
dc.description.abstract | Purpose: The estimated glomerular filtration rate (eGFR) at 6 months after donation (eGFR6m) is strongly associated with the risk of end-stage renal disease in living kidney donors. This study aimed to investigate the incidence of eGFR6m <60 mL/min/1.73 m2(eGFR6m <60) and identify the risk factors that can predict the occurrence of eGFR6m <60 in living kidney donors. Materials and Methods: Living kidney donors who underwent nephrectomy at Severance Hospital between January 2009 and December 2019 were identified. We excluded 94 of 1233 donors whose creatinine values at 6 months after donation were missing. The risk factors for eGFR6m <60 were assessed using multivariate regression analysis. The optimal cutoff points for candidate risk factors for predicting eGFR6m <60 occurrence were determined using the Youden index. Results: The eGFR6m <60 occurred in 17.3% of the participants. Older age (≥44 years), history of hypertension, lower preoperative eGFR (<101 mL/min/1.73 m2), and degree of increase in creatinine levels on postoperative day 2 compared to those before sur gery (ΔCr2_pre) (≥0.39 mg/dL) increased the risk of eGFR6m <60. The addition of ΔCr2_pre to preoperative eGFR yielded a higher predictive accuracy for predicting eGFR6m <60 than that with preoperative eGFR alone {area under the receiver operating charac teristic curve=0.886 [95% confidence interval (CI), 0.863–0.908] vs. 0.862 (95% CI, 0.838–0.887), p<0.001}. Conclusion: The incidence of eGFR6m <60 was 17.3%. Older age, lower preoperative eGFR, history of hypertension, and greater ΔCr2_pre were associated with the occurrence of eGFR6m <60 after living donor nephrectomy. The combination of preoperative eGFR and ΔCr2_pre showed the highest predictive power for eGFR6m <60. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Creatinine | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension* | - |
dc.subject.MESH | Kidney / physiology | - |
dc.subject.MESH | Kidney / surgery | - |
dc.subject.MESH | Kidney Transplantation* / adverse effects | - |
dc.subject.MESH | Living Donors | - |
dc.subject.MESH | Nephrectomy / adverse effects | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Association of Pre- and Post-Donation Renal Function with Midterm Estimated Glomerular Filtration Rate in Living Kidney Donors: A Retrospective Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Jin Ha Park | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | Jin Sun Cho | - |
dc.contributor.googleauthor | Dongkwan Shin | - |
dc.contributor.googleauthor | Sung Yeon Ham | - |
dc.contributor.googleauthor | Hyesu Kim | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.identifier.doi | 10.3349/ymj.2022.0541 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A00616 | - |
dc.contributor.localId | A01704 | - |
dc.contributor.localId | A03914 | - |
dc.contributor.localId | A05192 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 36825349 | - |
dc.subject.keyword | Creatinine | - |
dc.subject.keyword | eGFR at 6 months after donation | - |
dc.subject.keyword | estimated glomerular filtration rate | - |
dc.subject.keyword | living donor nephrectomy | - |
dc.subject.keyword | outcome | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | 곽영란 | - |
dc.contributor.affiliatedAuthor | 김소연 | - |
dc.contributor.affiliatedAuthor | 박진하 | - |
dc.contributor.affiliatedAuthor | 조진선 | - |
dc.contributor.affiliatedAuthor | 함성연 | - |
dc.citation.volume | 64 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 221 | - |
dc.citation.endPage | 227 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.64(3) : 221-227, 2023-03 | - |
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