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Pancreatoduodenectomy following neoadjuvant chemotherapy in duodenal adenocarcinoma

Authors
 Dongjin Seo  ;  Bo Gyeom Park  ;  Dawn Jung  ;  Ho Kyoung Hwang  ;  Sung Hyun Kim  ;  Seung Soo Hong  ;  Chang Moo Kang 
Citation
 Annals of Hepato-biliary-pancreatic Surgery, Vol.27(1) : 114-119, 2023-02 
Journal Title
Annals of Hepato-biliary-pancreatic Surgery
ISSN
 2508-5778 
Issue Date
2023-02
Keywords
Chemotherapy ; Duodenal cancer ; Laparoscopy ; Neoadjuvant therapy ; Pancreatoduodenectomy
Abstract
A 51-year-old male patient had four times of massive hematochezia episode three days before arrival. Carbohydrate antigen (CA) 19-9 level was extremely elevated. Computed tomography, magnetic resonance imaging, and positron emission tomography-computed tomography identified 5.7 cm sized periampullary duodenal cancer with regional metastatic lymph nodes and vascular invasion to aberrant right hepatic artery, main portal vein, and superior mesenteric vein. Diagnosed as duodenal adenocarcinoma through endoscopic biopsy, 16 times of FOLFIRI (5-fluorouracil, leucovorin, irinotecan) was conducted. The regimen changed to XELOX (capecitabine, oxaliplatine), four times of administration was done, and the CA19-9 level dramatically decreased. The tumor decreased to 2.1 cm. After R0 laparoscopic pylorus preserving pancreatoduodenectomy, no adjuvant therapy was given. No sign of recurrence or metastasis was reported, and the patient reached complete remission after five years. We reported a case where neoadjuvant chemotherapy for locally advanced duodenal adenocarcinoma was shown to be effective.
Files in This Item:
T202303603.pdf Download
DOI
10.14701/ahbps.22-069
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Kim, Sung Hyun(김성현) ORCID logo https://orcid.org/0000-0001-7683-9687
Hong, Seung Soo(홍승수)
Hwang, Ho Kyoung(황호경) ORCID logo https://orcid.org/0000-0003-4064-7776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/194002
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