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The Distinctive Immunologic Pathogenesis Differentiates Atopic Comorbidity Status in Prurigo Nodularis
DC Field | Value | Language |
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dc.contributor.author | 박창욱 | - |
dc.date.accessioned | 2023-04-07T01:33:56Z | - |
dc.date.available | 2023-04-07T01:33:56Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193991 | - |
dc.description.abstract | Background: Prurigo nodularis (PN) is a chronic pruritic skin disorder with a large number of hyperkeratoticnodules. The precise mechanisms of its pathogenesis remain unknown. PN has been linked to atopic dermatitis(AD), but its association remains unclear. Objective: We aimed to investigate the clinical, histological, and immunohistochemical characteristics of patientswith PN and PN underlying AD (PN-AD). Methods: Eight patients were recruited for PN, PN-AD, and eight normal subjects, respectively. Skin tissues wereobtained from patients and healthy subjects for histological and immunohistochemical analyses. Results: Histological examination showed increased epidermal thickness and dermal inflammatory cell counts in thePN-AD and PN groups compared to normal subjects. Immunohistochemical analyses revealed that the expression ofinterleukin (IL)-4, IL-13, IL-18, IL-31, IL-33, interferon (IFN)-γ, stromal-derived factor (SDF) 1-α and thymicstromal lymphopoietin (TSLP) was increased in the tissues of PN-AD and PN groups, in which the stainingintensities of IL-4, IL-13, SDF1-α and TSLP in the PN-AD group were higher than those in the PN group, but thedifferences were not statistically significant. Conversely, the staining intensities of IL-18, IL-33 and IFN-γ weresignificantly higher in the PN group than those in the PN-AD group. Conclusion: The pathogenesis of PN may differ from that of PN-AD, in which IL-18, IL-33 and IFN-γ may beassociated, implying that epidermal injury is the initial cause of IL-18 and IL-33 induction, which then increasesIFN-γ, resulting in the inflammatory process of PN. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | Korean | - |
dc.publisher | 대한피부과학회 | - |
dc.relation.isPartOf | Korean Journal of Dermatology(대한피부과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The Distinctive Immunologic Pathogenesis Differentiates Atopic Comorbidity Status in Prurigo Nodularis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Howard Chu | - |
dc.contributor.googleauthor | Wan Jin Kim | - |
dc.contributor.googleauthor | Su Min Kim | - |
dc.contributor.googleauthor | Seo Hyeong Kim | - |
dc.contributor.googleauthor | Ji Hye Kim | - |
dc.contributor.googleauthor | Kelun Zhang | - |
dc.contributor.googleauthor | Hye Li Kim | - |
dc.contributor.googleauthor | Ryeo Won Kim | - |
dc.contributor.googleauthor | Kwang Hoon Lee | - |
dc.contributor.googleauthor | Chang Ook Park | - |
dc.contributor.localId | A01716 | - |
dc.relation.journalcode | J02000 | - |
dc.identifier.url | https://kiss.kstudy.com/Detail/Ar?key=3991478 | - |
dc.subject.keyword | Atopic dermatitis | - |
dc.subject.keyword | Cytokines | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Prurigo | - |
dc.contributor.alternativeName | Park, Chang Ook | - |
dc.contributor.affiliatedAuthor | 박창욱 | - |
dc.citation.volume | 60 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 666 | - |
dc.citation.endPage | 674 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology(대한피부과학회지), Vol.60(10) : 666-674, 2022-12 | - |
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