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Successful treatment of renal malakoplakia via the reduction of immunosuppression and antimicrobial therapy after kidney transplantation: a case report
DC Field | Value | Language |
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dc.contributor.author | 김현정 | - |
dc.contributor.author | 임범진 | - |
dc.contributor.author | 임승혁 | - |
dc.contributor.author | 허규하 | - |
dc.contributor.author | 민은기 | - |
dc.date.accessioned | 2023-04-07T01:30:21Z | - |
dc.date.available | 2023-04-07T01:30:21Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 2671-8790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193959 | - |
dc.description.abstract | Malakoplakia is a rare, granulomatous disease that usually affects immunocompromised individuals and is generally associated with poor graft and patient survival. We present a case of renal malakoplakia after kidney transplantation (KT). A 33-year-old female patient with chronic kidney disease underwent living-donor KT at Severance Hospital. The patient was administered 375 mg/m2 rituximab due to high panel reactive antibodies. Immunosuppression was initiated with 1.5 mg/kg anti-thymocyte globulin and intravenous methylprednisolone and maintained with tacrolimus, oral methylprednisolone, and mycophenolate mofetil (MMF). Six months after KT, the patient was hospitalized for a urinary tract infection with an elevated serum creatinine level of 3.14 mg/dL. Renal biopsy revealed malakoplakia involving the renal parenchyma. Upon this diagnosis, the dose of tacrolimus was reduced and MMF was stopped. Fluoroquinolone was used for 16 days, and the trimethoprim/sulfamethoxazole dose was doubled for 6 days. The patient was hospitalized for 3 weeks and closely observed during outpatient visits. Follow-up ultrasonography revealed mass-like lesions of renal malakoplakia, which disappeared 5 months after diagnosis. The serum creatinine level decreased to 1.29 mg/dL 28 months after diagnosis. Our results suggest that renal malakoplakia can be successfully treated by the reduction of immunosuppression and sustained antimicrobial therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Society for Transplantation | - |
dc.relation.isPartOf | Korean Journal of Transplantation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Successful treatment of renal malakoplakia via the reduction of immunosuppression and antimicrobial therapy after kidney transplantation: a case report | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Seung Hyuk Yim | - |
dc.contributor.googleauthor | Eun-Ki Min | - |
dc.contributor.googleauthor | Hyun Jeong Kim | - |
dc.contributor.googleauthor | Beom Jin Lim | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.identifier.doi | 10.4285/kjt.22.0048 | - |
dc.contributor.localId | A06066 | - |
dc.contributor.localId | A03363 | - |
dc.contributor.localId | A06254 | - |
dc.contributor.localId | A04344 | - |
dc.relation.journalcode | J04229 | - |
dc.identifier.eissn | 2671-8804 | - |
dc.identifier.pmid | 36704813 | - |
dc.subject.keyword | Case report | - |
dc.subject.keyword | Graft rejections | - |
dc.subject.keyword | Immunosuppression | - |
dc.subject.keyword | Kidney transplantation | - |
dc.subject.keyword | Malakoplakia | - |
dc.contributor.alternativeName | Kim, Hyun Jeong | - |
dc.contributor.affiliatedAuthor | 김현정 | - |
dc.contributor.affiliatedAuthor | 임범진 | - |
dc.contributor.affiliatedAuthor | 임승혁 | - |
dc.contributor.affiliatedAuthor | 허규하 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 289 | - |
dc.citation.endPage | 293 | - |
dc.identifier.bibliographicCitation | Korean Journal of Transplantation, Vol.36(4) : 289-293, 2022-12 | - |
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