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Bifurcation strategies using second-generation drug-eluting stents on clinical outcomes in diabetic patients
DC Field | Value | Language |
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dc.contributor.author | 홍명기 | - |
dc.date.accessioned | 2023-04-07T01:28:12Z | - |
dc.date.available | 2023-04-07T01:28:12Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193939 | - |
dc.description.abstract | Background: Diabetes mellitus (DM) is a critical risk factor for the pathogenesis and progression of coronary artery disease, with a higher prevalence of complex coronary artery disease, including bifurcation lesions. This study aimed to elucidate the optimal stenting strategy for coronary bifurcation lesions in patients with DM. Methods: A total of 905 patients with DM and bifurcation lesions treated with second-generation drug-eluting stents (DES) from a multicenter retrospective patient cohort were analyzed. The primary outcome was the 5-year incidence of target lesion failure (TLF), which was defined as a composite of cardiac death, target vessel myocardial infarction, and target lesion revascularization. Results: Among all patients with DM with significant bifurcation lesions, 729 (80.6%) and 176 (19.4%) were treated with one- and two-stent strategies, respectively. TLF incidence differed according to the stenting strategy during the mean follow-up of 42 ± 20 months. Among the stent strategies, T- and V-stents were associated with a higher TLF incidence than one-stent strategy (24.0 vs. 7.3%, p < 0.001), whereas no difference was observed in TLF between the one-stent strategy and crush or culotte technique (7.3 vs. 5.9%, p = 0.645). The T- or V-stent technique was an independent predictor of TLF in multivariate analysis (hazard ratio, 3.592; 95% confidence interval, 2.117-6.095; p < 0.001). Chronic kidney disease, reduced left ventricular ejection fraction, and left main bifurcation were independent predictors of TLF in patients with DM. Conclusion: T- or V-stenting in patients with DM resulted in increased cardiovascular events after second-generation DES implantation. Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT03068494?term=03068494&draw=2&rank=1, identifier: NCT03068494. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Media S.A. | - |
dc.relation.isPartOf | FRONTIERS IN CARDIOVASCULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Bifurcation strategies using second-generation drug-eluting stents on clinical outcomes in diabetic patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jung-Joon Cha | - |
dc.contributor.googleauthor | Soon Jun Hong | - |
dc.contributor.googleauthor | Ju Hyeon Kim | - |
dc.contributor.googleauthor | Subin Lim | - |
dc.contributor.googleauthor | Hyung Joon Joo | - |
dc.contributor.googleauthor | Jae Hyoung Park | - |
dc.contributor.googleauthor | Cheol Woong Yu | - |
dc.contributor.googleauthor | Jeehoon Kang | - |
dc.contributor.googleauthor | Hyo-Soo Kim | - |
dc.contributor.googleauthor | Hyeon-Cheol Gwon | - |
dc.contributor.googleauthor | Woo Jung Chun | - |
dc.contributor.googleauthor | Seung-Ho Hur | - |
dc.contributor.googleauthor | Seung Hwan Han | - |
dc.contributor.googleauthor | Seung-Woon Rha | - |
dc.contributor.googleauthor | In-Ho Chae | - |
dc.contributor.googleauthor | Jin-Ok Jeong | - |
dc.contributor.googleauthor | Jung Ho Heo | - |
dc.contributor.googleauthor | Junghan Yoon | - |
dc.contributor.googleauthor | Jong-Seon Park | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.contributor.googleauthor | Joon-Hyung Doh | - |
dc.contributor.googleauthor | Kwang Soo Cha | - |
dc.contributor.googleauthor | Doo-Il Kim | - |
dc.contributor.googleauthor | Sang Yeub Lee | - |
dc.contributor.googleauthor | Kiyuk Chang | - |
dc.contributor.googleauthor | Byung-Hee Hwang | - |
dc.contributor.googleauthor | So-Yeon Choi | - |
dc.contributor.googleauthor | Myung Ho Jeong | - |
dc.contributor.googleauthor | Young Bin Song | - |
dc.contributor.googleauthor | Ki Hong Choi | - |
dc.contributor.googleauthor | Chang-Wook Nam | - |
dc.contributor.googleauthor | Bon-Kwon Koo | - |
dc.contributor.googleauthor | Do-Sun Lim | - |
dc.identifier.doi | 10.3389/fcvm.2022.1018802 | - |
dc.contributor.localId | A04391 | - |
dc.relation.journalcode | J04002 | - |
dc.identifier.eissn | 2297-055X | - |
dc.identifier.pmid | 36620646 | - |
dc.subject.keyword | clinical outcome | - |
dc.subject.keyword | coronary bifurcation angioplasty | - |
dc.subject.keyword | diabetes mellitus | - |
dc.subject.keyword | percutaneous coronary intervention (complex PCI) | - |
dc.subject.keyword | second-generation drug-eluting stent | - |
dc.subject.keyword | stent strategy | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | 홍명기 | - |
dc.citation.volume | 9 | - |
dc.citation.startPage | 1018802 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN CARDIOVASCULAR MEDICINE, Vol.9 : 1018802, 2022-12 | - |
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