Cited 36 times in
Multifunctional microrobot with real-time visualization and magnetic resonance imaging for chemoembolization therapy of liver cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 방승민 | - |
dc.date.accessioned | 2023-04-07T01:23:10Z | - |
dc.date.available | 2023-04-07T01:23:10Z | - |
dc.date.issued | 2022-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193906 | - |
dc.description.abstract | Microrobots that can be precisely guided to target lesions have been studied for in vivo medical applications. However, existing microrobots have challenges in vivo such as biocompatibility, biodegradability, actuation module, and intra- and postoperative imaging. This study reports microrobots visualized with real-time x-ray and magnetic resonance imaging (MRI) that can be magnetically guided to tumor feeding vessels for transcatheter liver chemoembolization in vivo. The microrobots, composed of a hydrogel-enveloped porous structure and magnetic nanoparticles, enable targeted delivery of therapeutic and imaging agents via magnetic guidance from the actuation module under real-time x-ray imaging. In addition, the microrobots can be tracked using MRI as postoperative imaging and then slowly degrade over time. The in vivo validation of microrobot system-mediated chemoembolization was demonstrated in a rat liver with a tumor model. The proposed microrobot provides an advanced medical robotic platform that can overcome the limitations of existing microrobots and current liver chemoembolization. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.relation.isPartOf | SCIENCE ADVANCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms* / diagnostic imaging | - |
dc.subject.MESH | Liver Neoplasms* / therapy | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Magnetics | - |
dc.subject.MESH | Robotics* | - |
dc.title | Multifunctional microrobot with real-time visualization and magnetic resonance imaging for chemoembolization therapy of liver cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Gwangjun Go | - |
dc.contributor.googleauthor | Ami Yoo | - |
dc.contributor.googleauthor | Kim Tien Nguyen | - |
dc.contributor.googleauthor | Minghui Nan | - |
dc.contributor.googleauthor | Bobby Aditya Darmawan | - |
dc.contributor.googleauthor | Shirong Zheng | - |
dc.contributor.googleauthor | Byungjeon Kang | - |
dc.contributor.googleauthor | Chang-Sei Kim | - |
dc.contributor.googleauthor | Doyeon Bang | - |
dc.contributor.googleauthor | Seonmin Lee | - |
dc.contributor.googleauthor | Kyu-Pyo Kim | - |
dc.contributor.googleauthor | Seong Soo Kang | - |
dc.contributor.googleauthor | Kyung Mi Shim | - |
dc.contributor.googleauthor | Se Eun Kim | - |
dc.contributor.googleauthor | Seungmin Bang | - |
dc.contributor.googleauthor | Deok-Ho Kim | - |
dc.contributor.googleauthor | Jong-Oh Park | - |
dc.contributor.googleauthor | Eunpyo Choi | - |
dc.identifier.doi | 10.1126/sciadv.abq8545 | - |
dc.contributor.localId | A01786 | - |
dc.relation.journalcode | J03735 | - |
dc.identifier.eissn | 2375-2548 | - |
dc.identifier.pmid | 36399561 | - |
dc.contributor.alternativeName | Bang, Seungmin | - |
dc.contributor.affiliatedAuthor | 방승민 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 46 | - |
dc.citation.startPage | eabq8545 | - |
dc.identifier.bibliographicCitation | SCIENCE ADVANCES, Vol.8(46) : eabq8545, 2022-11 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.