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혀에 발생한 전이성 미분화다형태육종 증례 보고

Other Titles
 Metastatic Undifferentiated Pleomorphic Sarcoma on Tongue: Case Report 
 김윤현  ;  홍진호  ;  정재환  ;  한승용  ;  김현실  ;  김형준 
 Korean Journal of Oral and Maxillofacial Pathology(대한구강악안면병리학회지), Vol.46(5) : 105-109, 2022-10 
Journal Title
Korean Journal of Oral and Maxillofacial Pathology(대한구강악안면병리학회지)
Issue Date
UPS ; Undifferentiated Pleomorphic Sarcoma ; RB1 ; Tongue metastasis ; Metastatic sarcoma
Sarcoma is rare malignant tumors that develop from mesenchymal cells. Metastasis to the oral cavity is a rare occurrence. Undifferentiated Pleomorphic sarcoma(UPS), formerly known as Malignant fibrous histiocytoma(MFH), is rare spindle cell neoplasm that can have poorly prognosis with metastasis and local recurrence. This report describes a case of a 77-year-old man who was diagnosed with Undifferentiated Pleomorphic Sarcoma of the chest wall and underwent adjuvant radiation therapy after surgical resection. Although there was success of wide excision, two years later, he presented with metastasis to the several organs including tongue. We retrospectively analyzed results of Next Generation Sequencing(NGS), and we figured out RB1 gene mutation. Until now targeted therapy of RB1 gene mutation is not established. Surgeon needs to consider metastatic tumors through identifying patients’ chief complaints and past medical & dental history. We need to research through NGS, and take a step closer to find targeted therapy for tumors.
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Kim, Hyung Jun(김형준) ORCID logo https://orcid.org/0000-0001-8247-4004
Han, Seung-Yong(한승용) ORCID logo https://orcid.org/0000-0002-9558-5384
Hong, Jin-Ho(홍진호)
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