154 331

Cited 1 times in

Clinical Spectrum and Treatment Outcomes of Patients with Developmental and/or Epileptic Encephalopathy with Spike-and-Wave Activation in Sleep

DC Field Value Language
dc.contributor.author강훈철-
dc.contributor.author김흥동-
dc.contributor.author이준수-
dc.contributor.author양동화-
dc.contributor.author김세희-
dc.contributor.author차누리-
dc.date.accessioned2023-04-07T01:14:24Z-
dc.date.available2023-04-07T01:14:24Z-
dc.date.issued2022-09-
dc.identifier.issn2035-909X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193837-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Child Neurology Society-
dc.relation.isPartOfAnnals of Child Neurology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHEpilepsy-
dc.subject.MESHPediatrics-
dc.subject.MESHElectroencephalography-
dc.subject.MESHSteroids-
dc.subject.MESHDiet, ketogenic-
dc.titleClinical Spectrum and Treatment Outcomes of Patients with Developmental and/or Epileptic Encephalopathy with Spike-and-Wave Activation in Sleep-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학교실)-
dc.contributor.googleauthorNuri Tchah-
dc.contributor.googleauthorDonghwa Yang-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorJoon Soo Lee-
dc.contributor.googleauthorSe Hee Kim-
dc.contributor.googleauthorHoon-Chul Kang-
dc.identifier.doi10.26815/acn.2022.00269-
dc.contributor.localIdA00102-
dc.contributor.localIdA01208-
dc.contributor.localIdA03177-
dc.relation.journalcodeJ03965-
dc.identifier.eissn2635-9103-
dc.subject.keywordPurpose Developmental and/or epileptic encephalopathy with spike-and-wave activation in sleep (D/EE-SWAS) is a spectrum of conditions characterized by various phenotypes of cognitive, linguistic, and behavioral regression associated with spike-and-wave activation in sleep. We aimed to investigate the phenotypic spectrum and treatment outcomes of pediatric patients with D/EE-SWAS. Methods We retrospectively analyzed the medical records of pediatric patients diagnosed with D/EE-SWAS and treated at Severance Children’s Hospital from 2006 to 2022. We extracted information from their medical records on electroencephalography before and after treatment, types of treatment, seizure frequency, and developmental profiles. The primary outcome was reduction of the spike-wave index on electroencephalography after treatment. Results Twenty-one patients with a median age of 5.3 years (interquartile range, 4.1 to 6.6) at diagnosis were included. Ten patients had delayed development. The patients received various anti-seizure medications. Fourteen received long-term, high-dose steroid therapy, 10 were placed on a ketogenic diet, four received intravenous steroid pulse therapy, and one each was treated with intravenous immunoglobulin and cannabidiol. The most effective treatments were steroid therapy and a ketogenic diet, which were also effective in reducing seizures and improving cognition. Side effects during treatment were transient and treatable. Conclusion We described the clinical spectrum of pediatric patients with D/EE-SWAS. Steroid therapy and a ketogenic diet can be considered effective therapeutic options for patients with D/EE SWAS.-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.contributor.affiliatedAuthor강훈철-
dc.contributor.affiliatedAuthor김흥동-
dc.contributor.affiliatedAuthor이준수-
dc.citation.volume30-
dc.citation.number4-
dc.citation.startPage189-
dc.citation.endPage196-
dc.identifier.bibliographicCitationAnnals of Child Neurology, Vol.30(4) : 189-196, 2022-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.