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Pre-treatment Nutritional Risk Assessment by NRS-2002 Predicts Prognosis in Patients With Advanced Biliary Tract Cancer: A Single Center Retrospective Study

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dc.contributor.author정희철-
dc.date.accessioned2023-04-07T01:12:03Z-
dc.date.available2023-04-07T01:12:03Z-
dc.date.issued2022-07-
dc.identifier.issn2287-3732-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193809-
dc.description.abstractWe investigated the predictors of survival in patients with advanced BTC according to their baseline nutritional status estimated by the Nutritional Risk Screening (NRS)-2002. From September 2006 to July 2017, we reviewed the data of 601 inpatients with BTC. Data on demographic and clinical parameters was collected from electronic medical records, and overall survival (OS) and progression-free survival were analyzed using the Kaplan-Meier method and the stepwise Cox regression analysis. Patients with an NRS-2002 score of ≤ 2, 3, and ≥ 4 were respectively classified as "no risk," "moderate risk," "high risk." Following initial NRS-2002 score, 333 patients (55%) were classified as "no-risk," 109 patients (18%) as "moderate-risk," and 159 patients (27%) as "high-risk." Survival analysis demonstrated significant differences in the median OS: "no-risk": 12.6 months (95% confidence interval [CI], 11.5-13.7); "moderate-risk": 6.1 months (95% CI, 4.3-8.0); and "high-risk": 3.9 months (95% CI, 3.2-4.6) (p < 0.001). NRS-2002 score was an independent factor for OS (hazard ratio [HR], 1.616 for "moderate-risk", 95% CI, 1.288-2.027, p < 0.001; HR, 2.121 for "high-risk", 95% CI, 1.722-2.612, p < 0.001), along with liver metastasis, peritoneal seeding, white blood cell count, platelet count, neutrophil-to-lymphocyte ratio, cholesterol, carcinoembryonic antigen, and carbohydrate antigen 19-9. In conclusion, baseline NRS-2002 is an appropriate method for discriminating those who are already malnourished and who have poor prognosis in advanced BTC patient. Significance of these results merit further validation to be integrated in the routine practice to improve quality of care in BTC patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society of Clinical Nutrition-
dc.relation.isPartOfClinical Nutrition Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePre-treatment Nutritional Risk Assessment by NRS-2002 Predicts Prognosis in Patients With Advanced Biliary Tract Cancer: A Single Center Retrospective Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSe Eung Oh-
dc.contributor.googleauthorJuong Soon Park-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.identifier.doi10.7762/cnr.2022.11.3.183-
dc.contributor.localIdA03794-
dc.relation.journalcodeJ00598-
dc.identifier.eissn2287-3740-
dc.identifier.pmid35949556-
dc.subject.keywordBiliary tract cancer-
dc.subject.keywordNutrition risk screening 2002 (NRS-2002)-
dc.subject.keywordPrognosis-
dc.subject.keywordSurvival-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.affiliatedAuthor정희철-
dc.citation.volume11-
dc.citation.number3-
dc.citation.startPage183-
dc.citation.endPage193-
dc.identifier.bibliographicCitationClinical Nutrition Research, Vol.11(3) : 183-193, 2022-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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