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Multidrug-Resistant Gram-Negative Bacterial Infections in a Tertiary-Care Hospital in Northern Ghana: A Three-Year Retrospective Analysis
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.date.accessioned | 2023-04-07T01:09:42Z | - |
dc.date.available | 2023-04-07T01:09:42Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 2288-0585 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193781 | - |
dc.description.abstract | Background: A variety of clinically important pathogens have developed multidrug resistance (MDR), which threatens global public health. This study aimed to determine the incidence, patterns, and trends of MDR of gram-negative bacterial isolates in clinical specimens in the Tamale Teaching Hospital, Ghana. Methods: This retrospective study analyzed gram-negative bacterial isolates and antimicrobial susceptibility test (AST) results of patients who visited the Tamale Teaching Hospital laboratory between 2017 and 2019. Results: A total of 2,779 gram-negative bacterial isolates and their phenotypic AST results were analyzed. From these, 1,297 gram-negative bacteria (46.7%) were isolated from urine samples, while the rest were isolated from sputum (20.9%), wound (14.3%), and swabs (11.7%) samples, etc. Escherichia coli (23.8%) was the most common gram-negative pathogen found predominantly in the urine samples (33.2%). All gram-negative bacteria isolated between 2017 and 2019 showed high MDR. Klebsiella pneumoniae gradually increased its MDR from 84.0% in 2017, 89.5% in 2018, to 95.1% in 2019. On the other hand, the MDR rates in Pseudomonas aeruginosa were approximately 65.8%, varying from 59.5% in 2017 to 78.7% in 2019. Among tested antimicrobials, amikacin was the most effective. Resistance to amikacin in Enterobacter spp., E. coli, and K. pneumoniae in vitro were 16.2%, 11.8%, and 17.7%, respectively. Conclusion: The study has shown that the high levels of MDR in gram-negative bacteria isolated may be associated with the infections recorded at the Tamale Teaching Hospital. The major gram-negative pathogens isolated have resistance to penicillins, cephalosporins, and fluoroquinolones. Aminoglycosides can offer high antibiotic activity to overcome gram-negative bacterial resistance. Further studies will be needed to decide policy direction on infection prevention and control, and antimicrobial stewardship programs | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Clinical Microbiology | - |
dc.relation.isPartOf | Annals of Clinical Microbiology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Multidrug-Resistant Gram-Negative Bacterial Infections in a Tertiary-Care Hospital in Northern Ghana: A Three-Year Retrospective Analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Kennedy Mensah Osei | - |
dc.contributor.googleauthor | Heekang Choi | - |
dc.contributor.googleauthor | Zeyeh David Eklu | - |
dc.contributor.googleauthor | Alikamatu Salifu | - |
dc.contributor.googleauthor | Owusu Boateng Esther | - |
dc.contributor.googleauthor | Vandarith Nov | - |
dc.contributor.googleauthor | Nguyen Le Phuong | - |
dc.contributor.googleauthor | Kubura Khadija | - |
dc.contributor.googleauthor | Bobzah Bernard | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.identifier.doi | 10.5145/ACM.2022.25.1.1 | - |
dc.contributor.localId | A02423 | - |
dc.relation.journalcode | J00156 | - |
dc.identifier.eissn | 2288-6850 | - |
dc.subject.keyword | Gram-negative bacteria | - |
dc.subject.keyword | Multidrug resistance | - |
dc.subject.keyword | Tamale Teaching Hospital | - |
dc.subject.keyword | Ghana | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | 용동은 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 45 | - |
dc.citation.endPage | 51 | - |
dc.identifier.bibliographicCitation | Annals of Clinical Microbiology, Vol.25(2) : 45-51, 2022-03 | - |
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