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Association between Low-Density Lipoprotein Cholesterol Level and Cardiovascular Outcomes in Korean Adults: A Nationwide Cohort Study
DC Field | Value | Language |
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dc.contributor.author | 김현창 | - |
dc.date.accessioned | 2023-03-27T02:43:38Z | - |
dc.date.available | 2023-03-27T02:43:38Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193681 | - |
dc.description.abstract | Background: To validate the treatment target of low-density lipoprotein cholesterol (LDL-C) level according to the cardiovascular disease (CVD) risk which was recommended by Korean dyslipidemia guideline. Methods: We used the Korean National Health Insurance Service database which included 3,958,048 people aged 20 to 89 years who underwent regular health screening. The primary outcome was incident CVD, defined as a composite of myocardial infarction and stroke during the follow-up period from 2009 to 2018. Results: The risk of CVD increased from LDL-C level of 70 mg/dL in very high-risk and high-risk groups and from 130 mg/dL in moderate-risk and low-risk groups. Adjusted hazard ratios (HRs) of LDL-C ranges 70-99, 100-129, 130-159, 160-189, and ≥190 mg/dL were 1.20 (95% confidence interval [CI], 1.08-1.33), 1.27 (1.15-1.42), 1.39 (1.23-1.56), 1.69 (1.45-1.96), and 1.84 (1.49- 2.27) in very high-risk group, and 1.07 (1.02-1.13), 1.16 (1.10-1.21), 1.29 (1.22-1.36), 1.45 (1.36-1.55), and 1.73 (1.58-1.90) in high-risk group. Adjusted HRs (95% CI) of LDL-C ranges 130-159, 160-189, and ≥190 mg/dL were 1.15 (1.11-1.20), 1.28 (1.22- 1.34), and 1.45 (1.36-1.54) in moderate-risk group and 1.07 (1.02-1.13), 1.20 (1.13-1.26), and 1.47 (1.37-1.57) in low-risk group. Conclusion: We confirmed the incidence of CVD was increased in higher LDL-C range. The risk of CVD increased from ≥70 mg/dL of LDL-C in very high-risk and high-risk groups, and from ≥130 mg/dL of LDL-C in moderate-risk and low-risk groups in Korean adults. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Diabetes Association | - |
dc.relation.isPartOf | DIABETES & METABOLISM JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cardiovascular Diseases* / epidemiology | - |
dc.subject.MESH | Cholesterol, LDL | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Association between Low-Density Lipoprotein Cholesterol Level and Cardiovascular Outcomes in Korean Adults: A Nationwide Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학교실) | - |
dc.contributor.googleauthor | Junghyun Noh | - |
dc.contributor.googleauthor | Min Kyong Moon | - |
dc.contributor.googleauthor | Eun-Jung Rhee | - |
dc.contributor.googleauthor | Sang Hyun Park | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.contributor.googleauthor | Byung Jin Kim | - |
dc.contributor.googleauthor | Hae Jin Kim | - |
dc.contributor.googleauthor | Seonghoon Choi | - |
dc.contributor.googleauthor | Jin Oh Na | - |
dc.contributor.googleauthor | Young Youl Hyun | - |
dc.contributor.googleauthor | Bum Joon Kim | - |
dc.contributor.googleauthor | Kyung-Do Han | - |
dc.contributor.googleauthor | In-Kyung Jeong | - |
dc.identifier.doi | 10.4093/dmj.2021.0320 | - |
dc.contributor.localId | A01142 | - |
dc.relation.journalcode | J00720 | - |
dc.identifier.eissn | 2233-6087 | - |
dc.identifier.pmid | 36727164 | - |
dc.subject.keyword | Cardiovascular diseases | - |
dc.subject.keyword | Cholesterol | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | LDL | - |
dc.contributor.alternativeName | Kim, Hyeon Chang | - |
dc.contributor.affiliatedAuthor | 김현창 | - |
dc.citation.volume | 47 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 59 | - |
dc.citation.endPage | 71 | - |
dc.identifier.bibliographicCitation | DIABETES & METABOLISM JOURNAL, Vol.47(1) : 59-71, 2023-01 | - |
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