Cited 11 times in
Accuracy of Noninvasive Scoring Systems in Assessing Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | 이혜원 | - |
dc.date.accessioned | 2023-03-22T05:43:35Z | - |
dc.date.available | 2023-03-22T05:43:35Z | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193656 | - |
dc.description.abstract | Background/aims: Several noninvasive scoring systems have been developed to determine the risk of advanced fibrosis in nonalcoholic fatty liver disease (NAFLD). We examined the diagnostic accuracy of the fibrosis-4 (FIB-4) score and NAFLD fibrosis score (NFS) in patients with biopsy-proven NAFLD. Methods: For this meta-analysis, various databases including PubMed (MEDLINE), EMBASE, OVID Medline and the Cochrane Library were systematically searched. After the acquired abstracts were reviewed by two investigators, manuscripts were chosen for a full-text examination. Results: Thirty-six studies evaluating biopsy-proven NAFLD were selected for meta-analysis. A total of 14,992 patients were analyzed. The lower cutoff sensitivity of the FIB-4 score predicting histological fibrosis stage 3 or more (≥F3) was 69%, with specificity of 64%, positive likelihood ratio (LR+) of 1.96, and negative likelihood ratio (LR-) of 0.47. The low baseline sensitivity of the NFS score predicting ≥F3 was 70%, with a specificity of 61%, LR+ of 1.83, and LR- of 0.48. The area under the receiver operating characteristic curve (AUC) values of the FIB-4 score predicting ≥F3 and ≥F2 were 76% and 68%, respectively. The AUC values of the NFS score predicting ≥F3 and ≥F2 were 74% and 60%, respectively. Conclusions: The FIB-4 or NFS test can be used to predict the degree of liver fibrosis in NAFLD, and the diagnostic accuracy resulted as relatively high in fibrosis stages of F3 or higher. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Editorial Office of Gut and Liver | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Alanine Transaminase | - |
dc.subject.MESH | Aspartate Aminotransferases | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver / pathology | - |
dc.subject.MESH | Liver Cirrhosis / diagnosis | - |
dc.subject.MESH | Liver Cirrhosis / etiology | - |
dc.subject.MESH | Liver Cirrhosis / pathology | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease* / complications | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease* / pathology | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.title | Accuracy of Noninvasive Scoring Systems in Assessing Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sangsoo Han | - |
dc.contributor.googleauthor | Miyoung Choi | - |
dc.contributor.googleauthor | Bora Lee | - |
dc.contributor.googleauthor | Hye-Won Lee | - |
dc.contributor.googleauthor | Seong Hee Kang | - |
dc.contributor.googleauthor | Yuri Cho | - |
dc.contributor.googleauthor | Sang Bong Ahn | - |
dc.contributor.googleauthor | Do Seon Song | - |
dc.contributor.googleauthor | Dae Won Jun | - |
dc.contributor.googleauthor | Jieun Lee | - |
dc.contributor.googleauthor | Jeong-Ju Yoo | - |
dc.identifier.doi | 10.5009/gnl210391 | - |
dc.contributor.localId | A03318 | - |
dc.relation.journalcode | J00954 | - |
dc.identifier.eissn | 2005-1212 | - |
dc.identifier.pmid | 35193993 | - |
dc.subject.keyword | Liver fibrosis | - |
dc.subject.keyword | Meta-analysis | - |
dc.subject.keyword | Nonalcoholic fatty liver disease | - |
dc.subject.keyword | Predictive value of tests | - |
dc.contributor.alternativeName | Lee, Hye Won | - |
dc.contributor.affiliatedAuthor | 이혜원 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 952 | - |
dc.citation.endPage | 963 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, Vol.16(6) : 952-963, 2022-11 | - |
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