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Clinical Outcomes of Endoscope-Assisted Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension

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dc.contributor.author김효현-
dc.contributor.author윤영남-
dc.date.accessioned2023-03-22T02:38:45Z-
dc.date.available2023-03-22T02:38:45Z-
dc.date.issued2023-02-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193638-
dc.description.abstractPurpose: Pulmonary thromboembolism is a potentially life-threatening condition in patients with heart disease; however, limited studies discussing long-term outcomes exist. This study aimed to investigate the long-term outcomes of pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH), focusing on the improvement of functional class and right ventricular (RV) pressure. Materials and methods: Clinical data of patients with CTEPH were obtained from Yonsei Hospital between May 2012 and December 2021, and reviewed retrospectively. Twenty-six patients underwent endoscope-guided PEA during the study period, and the mean follow-up duration was 24.8±23.4 months. Results: After PEA, most patients (88.5%) were weaned from inotropes without extracorporeal membrane oxygenation support during the first few days. Two patients (7.6%) had cerebrovascular accidents without neurological deficits. On echocardiography, the RV systolic pressure and tricuspid regurgitation grades significantly improved (p<0.001). Furthermore, the mean left ventricle end-diastolic diameter was significant increased (p=0.003), and the left ventricular end-systolic diameter increased (p<0.001). The median intensive care unit stay was 3.0±9.4 days, and median hospital stay 16.0±26.5 days. The 5-year survival rate was 95.5%, and the 5-year freedom rate of cardiac death was 100%. There was a marked improvement in New York Heart Association (NYHA) status (p<0.001). Cox regression suggested that the main pulmonary artery (MPA) involvement is a significant predictor of non-improvement in functional class post-PEA. Conclusion: Mortality rates are low and patients experience a marked improvement in NYHA class and health status after PEA. Moreover, MPA involvement may affect functional outcomes.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHChronic Disease-
dc.subject.MESHEndarterectomy / adverse effects-
dc.subject.MESHHumans-
dc.subject.MESHHypertension, Pulmonary* / etiology-
dc.subject.MESHHypertension, Pulmonary* / surgery-
dc.subject.MESHPulmonary Artery / surgery-
dc.subject.MESHPulmonary Embolism* / surgery-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titleClinical Outcomes of Endoscope-Assisted Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.googleauthorHyo-Hyun Kim-
dc.contributor.googleauthorHyun-Soo Lee-
dc.contributor.googleauthorHyun-Sik Kim-
dc.contributor.googleauthorYoung-Nam Youn-
dc.identifier.doi10.3349/ymj.2022.0437-
dc.contributor.localIdA04741-
dc.contributor.localIdA02576-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid36719017-
dc.subject.keywordPulmonary arterial hypertension-
dc.subject.keywordendarterectomy-
dc.subject.keywordfunctional status-
dc.contributor.alternativeNameKim, Hyohyun-
dc.contributor.affiliatedAuthor김효현-
dc.contributor.affiliatedAuthor윤영남-
dc.citation.volume64-
dc.citation.number2-
dc.citation.startPage104-
dc.citation.endPage110-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.64(2) : 104-110, 2023-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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