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Clinical Outcomes of Endoscope-Assisted Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension
DC Field | Value | Language |
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dc.contributor.author | 김효현 | - |
dc.contributor.author | 윤영남 | - |
dc.date.accessioned | 2023-03-22T02:38:45Z | - |
dc.date.available | 2023-03-22T02:38:45Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193638 | - |
dc.description.abstract | Purpose: Pulmonary thromboembolism is a potentially life-threatening condition in patients with heart disease; however, limited studies discussing long-term outcomes exist. This study aimed to investigate the long-term outcomes of pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH), focusing on the improvement of functional class and right ventricular (RV) pressure. Materials and methods: Clinical data of patients with CTEPH were obtained from Yonsei Hospital between May 2012 and December 2021, and reviewed retrospectively. Twenty-six patients underwent endoscope-guided PEA during the study period, and the mean follow-up duration was 24.8±23.4 months. Results: After PEA, most patients (88.5%) were weaned from inotropes without extracorporeal membrane oxygenation support during the first few days. Two patients (7.6%) had cerebrovascular accidents without neurological deficits. On echocardiography, the RV systolic pressure and tricuspid regurgitation grades significantly improved (p<0.001). Furthermore, the mean left ventricle end-diastolic diameter was significant increased (p=0.003), and the left ventricular end-systolic diameter increased (p<0.001). The median intensive care unit stay was 3.0±9.4 days, and median hospital stay 16.0±26.5 days. The 5-year survival rate was 95.5%, and the 5-year freedom rate of cardiac death was 100%. There was a marked improvement in New York Heart Association (NYHA) status (p<0.001). Cox regression suggested that the main pulmonary artery (MPA) involvement is a significant predictor of non-improvement in functional class post-PEA. Conclusion: Mortality rates are low and patients experience a marked improvement in NYHA class and health status after PEA. Moreover, MPA involvement may affect functional outcomes. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Chronic Disease | - |
dc.subject.MESH | Endarterectomy / adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension, Pulmonary* / etiology | - |
dc.subject.MESH | Hypertension, Pulmonary* / surgery | - |
dc.subject.MESH | Pulmonary Artery / surgery | - |
dc.subject.MESH | Pulmonary Embolism* / surgery | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Clinical Outcomes of Endoscope-Assisted Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.googleauthor | Hyo-Hyun Kim | - |
dc.contributor.googleauthor | Hyun-Soo Lee | - |
dc.contributor.googleauthor | Hyun-Sik Kim | - |
dc.contributor.googleauthor | Young-Nam Youn | - |
dc.identifier.doi | 10.3349/ymj.2022.0437 | - |
dc.contributor.localId | A04741 | - |
dc.contributor.localId | A02576 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 36719017 | - |
dc.subject.keyword | Pulmonary arterial hypertension | - |
dc.subject.keyword | endarterectomy | - |
dc.subject.keyword | functional status | - |
dc.contributor.alternativeName | Kim, Hyohyun | - |
dc.contributor.affiliatedAuthor | 김효현 | - |
dc.contributor.affiliatedAuthor | 윤영남 | - |
dc.citation.volume | 64 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 104 | - |
dc.citation.endPage | 110 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.64(2) : 104-110, 2023-02 | - |
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