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Longitudinal association between adiposity changes and lung function deterioration

DC Field Value Language
dc.contributor.author김영삼-
dc.contributor.author김지영-
dc.contributor.author박무석-
dc.contributor.author박영목-
dc.contributor.author임아영-
dc.contributor.author정경수-
dc.contributor.author정지예-
dc.date.accessioned2023-03-22T02:32:12Z-
dc.date.available2023-03-22T02:32:12Z-
dc.date.issued2023-02-
dc.identifier.issn1465-9921-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193622-
dc.description.abstractBackground: The longitudinal relationship between adiposity and lung function is controversial. We aimed to investigate the long-term association between adiposity changes and lung function in a middle-aged general Asian population. Methods: In total, 5011 participants (average age, 54 years; 45% men) were enrolled from a community-based prospective cohort. During the follow-up period (median 8 years), both spirometry and bio-electrical impedance analysis were performed biannually. Individual slopes of the fat mass index (FMI; fat mass divided by the square of height in meters) and waist-to-hip ratio (WHR) were calculated using linear regression analysis. Multivariate linear mixed regression analysis was used to determine the long-term association between adiposity changes and lung function. Results: The FMI was inversely associated with forced vital capacity (FVC) (estimated: - 31.8 mL in men, - 27.8 mL in women) and forced expiratory volume in 1 s (FEV1) (estimated: - 38.2 mL in men, - 17.8 mL in women) after adjusting for baseline age, height, residential area, smoking exposure (pack-years, men only), initial adiposity indices, and baseline lung function. The WHR was also inversely associated with FVC (estimated = - 1242.2 mL) and FEV1 (estimated = - 849.8 mL) in men. The WHR-increased group showed a more rapid decline in lung function than the WHR-decreased group in both the fat-gain and fat-loss groups. Conclusion: Adiposity was associated with the long-term impairment of lung function. Central obesity was the main driver of lung function impairment in the middle-aged general Asian population, regardless of fat mass changes.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central Ltd-
dc.relation.isPartOfRESPIRATORY RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdiposity*-
dc.subject.MESHBody Mass Index-
dc.subject.MESHFemale-
dc.subject.MESHForced Expiratory Volume-
dc.subject.MESHHumans-
dc.subject.MESHLung*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHObesity / epidemiology-
dc.subject.MESHProspective Studies-
dc.subject.MESHVital Capacity-
dc.titleLongitudinal association between adiposity changes and lung function deterioration-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYoungmok Park-
dc.contributor.googleauthorJiyoung Kim-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorAh Young Leem-
dc.contributor.googleauthorJinyeon Jo-
dc.contributor.googleauthorKyungsoo Chung-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorSungho Won-
dc.contributor.googleauthorJi Ye Jung -
dc.identifier.doi10.1186/s12931-023-02322-8-
dc.contributor.localIdA00707-
dc.contributor.localIdA06228-
dc.contributor.localIdA01457-
dc.contributor.localIdA05828-
dc.contributor.localIdA03382-
dc.contributor.localIdA03570-
dc.contributor.localIdA03735-
dc.relation.journalcodeJ02616-
dc.identifier.eissn1465-993X-
dc.identifier.pmid36750832-
dc.subject.keywordAbdominal obesity-
dc.subject.keywordAdiposity-
dc.subject.keywordBody composition-
dc.subject.keywordSpirometry-
dc.subject.keywordWaist–hip ratio-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.affiliatedAuthor김영삼-
dc.contributor.affiliatedAuthor김지영-
dc.contributor.affiliatedAuthor박무석-
dc.contributor.affiliatedAuthor박영목-
dc.contributor.affiliatedAuthor임아영-
dc.contributor.affiliatedAuthor정경수-
dc.contributor.affiliatedAuthor정지예-
dc.citation.volume24-
dc.citation.number1-
dc.citation.startPage44-
dc.identifier.bibliographicCitationRESPIRATORY RESEARCH, Vol.24(1) : 44, 2023-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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