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Longitudinal association between adiposity changes and lung function deterioration

Authors
 Youngmok Park  ;  Jiyoung Kim  ;  Young Sam Kim  ;  Ah Young Leem  ;  Jinyeon Jo  ;  Kyungsoo Chung  ;  Moo Suk Park  ;  Sungho Won  ;  Ji Ye Jung  
Citation
 RESPIRATORY RESEARCH, Vol.24(1) : 44, 2023-02 
Journal Title
RESPIRATORY RESEARCH
ISSN
 1465-9921 
Issue Date
2023-02
MeSH
Adiposity* ; Body Mass Index ; Female ; Forced Expiratory Volume ; Humans ; Lung* ; Male ; Middle Aged ; Obesity / epidemiology ; Prospective Studies ; Vital Capacity
Keywords
Abdominal obesity ; Adiposity ; Body composition ; Spirometry ; Waist–hip ratio
Abstract
Background: The longitudinal relationship between adiposity and lung function is controversial. We aimed to investigate the long-term association between adiposity changes and lung function in a middle-aged general Asian population.

Methods: In total, 5011 participants (average age, 54 years; 45% men) were enrolled from a community-based prospective cohort. During the follow-up period (median 8 years), both spirometry and bio-electrical impedance analysis were performed biannually. Individual slopes of the fat mass index (FMI; fat mass divided by the square of height in meters) and waist-to-hip ratio (WHR) were calculated using linear regression analysis. Multivariate linear mixed regression analysis was used to determine the long-term association between adiposity changes and lung function.

Results: The FMI was inversely associated with forced vital capacity (FVC) (estimated: - 31.8 mL in men, - 27.8 mL in women) and forced expiratory volume in 1 s (FEV1) (estimated: - 38.2 mL in men, - 17.8 mL in women) after adjusting for baseline age, height, residential area, smoking exposure (pack-years, men only), initial adiposity indices, and baseline lung function. The WHR was also inversely associated with FVC (estimated = - 1242.2 mL) and FEV1 (estimated = - 849.8 mL) in men. The WHR-increased group showed a more rapid decline in lung function than the WHR-decreased group in both the fat-gain and fat-loss groups.

Conclusion: Adiposity was associated with the long-term impairment of lung function. Central obesity was the main driver of lung function impairment in the middle-aged general Asian population, regardless of fat mass changes.
Files in This Item:
T202301070.pdf Download
DOI
10.1186/s12931-023-02322-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Ji Yeong(김지영)
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Park, Youngmok(박영목) ORCID logo https://orcid.org/0000-0002-5669-1491
Leem, Ah Young(임아영) ORCID logo https://orcid.org/0000-0001-5165-3704
Jung, Kyung Soo(정경수) ORCID logo https://orcid.org/0000-0003-1604-8730
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193622
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