Cited 3 times in
Association Between Proton Pump Inhibitor Exposure and Acute Kidney Injury After Cardiac Surgery
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.contributor.author | 김형우 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 이명지 | - |
dc.contributor.author | 주영수 | - |
dc.contributor.author | 지종현 | - |
dc.contributor.author | 한민경 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 고희병 | - |
dc.date.accessioned | 2023-03-22T02:27:27Z | - |
dc.date.available | 2023-03-22T02:27:27Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 0025-6196 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193607 | - |
dc.description.abstract | Objective: To evaluate the association of preoperative proton pump inhibitor (PPI) exposure with incident acute kidney injury (AKI) after cardiac surgery. Patients and methods: The Severance cardiac surgery cohort included 9860 cardiac surgery patients aged 18 years or older. The National Health Insurance Service-senior cohort included 2933 patients aged 60 years or older who underwent cardiac surgery. Preoperative PPI exposure was defined as a PPI prescription within 3 weeks prior to cardiac surgery. Primary outcomes were postoperative AKI and AKI requiring dialysis (AKI-dialysis). Results: In the Severance cardiac surgery cohort after propensity score matching for PPI exposure, incident AKI (44.0% [472 of 1073] vs 40.5% [1304 of 3219]) and AKI-dialysis (5.8% [62 of 1073] vs 3.7% [119 of 3219]) were more common in patients exposed to PPI than in those who were not. Hospital and intensive care unit stay durations were longer among PPI-exposed than PPI-nonexposed patients. Multivariable conditional logistic analyses revealed that PPI exposure was significantly associated with incident AKI (adjusted odds ratio [AOR], 1.21; 95% CI, 1.03 to 1.42; P=.02) and AKI-dialysis (AOR, 1.74; 95% CI, 1.15 to 2.63; P=.009). The National Health Insurance Service-Senior cohort had similar results, revealing a significant association between PPI exposure and incident AKI-dialysis (AOR, 1.87; 95% CI, 1.25 to 2.81; P=.003). Discontinuation of PPI prior to operation was associated with a lower odds of AKI development in both cohorts. Conclusion: Preoperative PPI exposure may be a modifiable risk factor for AKI among patients undergoing cardiac surgery. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mayo Foundation for Medical Education and Research | - |
dc.relation.isPartOf | MAYO CLINIC PROCEEDINGS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acute Kidney Injury* / chemically induced | - |
dc.subject.MESH | Acute Kidney Injury* / epidemiology | - |
dc.subject.MESH | Cardiac Surgical Procedures* / adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Postoperative Complications / chemically induced | - |
dc.subject.MESH | Postoperative Complications / epidemiology | - |
dc.subject.MESH | Proton Pump Inhibitors / adverse effects | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Association Between Proton Pump Inhibitor Exposure and Acute Kidney Injury After Cardiac Surgery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hee Byung Koh | - |
dc.contributor.googleauthor | Young Su Joo | - |
dc.contributor.googleauthor | Hyung Woo Kim | - |
dc.contributor.googleauthor | Wonji Jo | - |
dc.contributor.googleauthor | Shin Chan Kang | - |
dc.contributor.googleauthor | Jong Hyun Jhee | - |
dc.contributor.googleauthor | Minkyung Han | - |
dc.contributor.googleauthor | Myeongjee Lee | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.identifier.doi | 10.1016/j.mayocp.2022.07.024 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A01151 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A05996 | - |
dc.contributor.localId | A03956 | - |
dc.contributor.localId | A03970 | - |
dc.contributor.localId | A05436 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J03669 | - |
dc.identifier.eissn | 1942-5546 | - |
dc.identifier.pmid | 36737115 | - |
dc.identifier.url | https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0025619622004669 | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 김형우 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 이명지 | - |
dc.contributor.affiliatedAuthor | 주영수 | - |
dc.contributor.affiliatedAuthor | 지종현 | - |
dc.contributor.affiliatedAuthor | 한민경 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 98 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 266 | - |
dc.citation.endPage | 277 | - |
dc.identifier.bibliographicCitation | MAYO CLINIC PROCEEDINGS, Vol.98(2) : 266-277, 2023-02 | - |
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