Cited 4 times in
Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이우정 | - |
dc.date.accessioned | 2023-03-21T07:38:25Z | - |
dc.date.available | 2023-03-21T07:38:25Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193483 | - |
dc.description.abstract | Several treatment guidelines for sporadic, nonmetastatic nonfunctioning neuroendocrine tumors of the pancreas (NF-pNETs) have recommended resection, however, tumors ≤ 2 cm do not necessarily need surgery. This study aims to establish a surgical treatment plan for NF-pNETs ≤ 2 cm. From 2000 to 2017, 483 patients who underwent resection for NF-pNETs ≤ 2 cm in 18 institutions from Korea and China were enrolled and their medical records were reviewed. The median age was 56 (range 16-80) years. The 10-year overall survival rate (10Y-OS) and recurrence-free survival rate (10Y-RFS) were 89.8 and 93.1%, respectively. In multivariable analysis, tumor size (>1.5 cm; HR 4.28, 95% CI 1.80-10.18, p = 0.001) and nodal metastasis (HR 3.32, 95% CI 1.29-8.50, p = 0.013) were independent adverse prognostic factors for OS. Perineural invasion (HR 4.36, 95% CI 1.48-12.87, p = 0.008) and high Ki-67 index (≥3%; HR 9.06, 95% CI 3.01-27.30, p < 0.001) were independent prognostic factors for poor RFS. NF-pNETs ≤ 2 cm showed unfavorable prognosis after resection when the tumor was larger than 1.5 cm, Ki-67 index ≥ 3%, or nodal metastasis was present. NF-pNET patients with tumors ≤ 1.5 cm can be observed if the preoperative Ki-67 index is under 3%, and if nodal metastasis is not suspected in preoperative radiologic studies. These findings support the clinical use to make decisions about small NF-pNETs. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | In Woong Han | - |
dc.contributor.googleauthor | Jangho Park | - |
dc.contributor.googleauthor | Eun Young Park | - |
dc.contributor.googleauthor | So Jeong Yoon | - |
dc.contributor.googleauthor | Gang Jin | - |
dc.contributor.googleauthor | Dae Wook Hwang | - |
dc.contributor.googleauthor | Kuirong Jiang | - |
dc.contributor.googleauthor | Wooil Kwon | - |
dc.contributor.googleauthor | Xuefeng Xu | - |
dc.contributor.googleauthor | Jin Seok Heo | - |
dc.contributor.googleauthor | De-Liang Fu | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.contributor.googleauthor | Xueli Bai | - |
dc.contributor.googleauthor | Yoo-Seok Yoon | - |
dc.contributor.googleauthor | Yin-Mo Yang | - |
dc.contributor.googleauthor | Keun Soo Ahn | - |
dc.contributor.googleauthor | Chunhui Yuan | - |
dc.contributor.googleauthor | Hyeon Kook Lee | - |
dc.contributor.googleauthor | Bei Sun | - |
dc.contributor.googleauthor | Eun Kyu Park | - |
dc.contributor.googleauthor | Seung Eun Lee | - |
dc.contributor.googleauthor | Sunghwa Kang | - |
dc.contributor.googleauthor | Wenhui Lou | - |
dc.contributor.googleauthor | Sang-Jae Park | - |
dc.identifier.doi | 10.3390/cancers14041038 | - |
dc.contributor.localId | A02993 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 35205787 | - |
dc.subject.keyword | nonfunctioning neuroendocrine tumor of pancreas | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | resection | - |
dc.subject.keyword | risk factors | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | 이우정 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1038 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.14(4) : 1038, 2022-02 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.