Cited 64 times in
Asian perspective on NAFLD-associated HCC
DC Field | Value | Language |
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dc.contributor.author | 이혜원 | - |
dc.date.accessioned | 2023-03-21T07:38:06Z | - |
dc.date.available | 2023-03-21T07:38:06Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193479 | - |
dc.description.abstract | Recent data suggest that non-alcoholic fatty liver disease (NAFLD) has become a major public health problem in Asia, with an updated population prevalence of 34%. In parallel, NAFLD-associated hepatocellular carcinoma (HCC) is also on the rise. In this review, we describe the changing epidemiology of HCC in Asia over the past 30 years. While traditional risk factors for HCC (older age, male sex and metabolic factors) are also important in Asia, the PNPLA3 gene polymorphism is particularly prevalent in East Asia and may increase the risk of HCC. NAFLD among non-obese individuals is also commonly described in Asia. Because NAFLD is often undiagnosed, few patients receive HCC surveillance, and the target surveillance population beyond patients with cirrhosis remains poorly defined. As a result, NAFLD-associated HCC is often diagnosed at an advanced stage, rendering curative treatment impossible. Finally, despite around 20-30 years of universal vaccination, chronic HBV infection remains prevalent in Asia, and emerging evidence highlights the importance of metabolic factors and concomitant hepatic steatosis on HCC development in infected patients. Future studies should explore the role of metabolic treatments in HCC prevention among patients with hepatic steatosis and concomitant liver diseases. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Asia / epidemiology | - |
dc.subject.MESH | Asia / ethnology | - |
dc.subject.MESH | Asian People / ethnology | - |
dc.subject.MESH | Asian People / statistics & numerical data* | - |
dc.subject.MESH | Carcinoma, Hepatocellular / epidemiology* | - |
dc.subject.MESH | Carcinoma, Hepatocellular / ethnology | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms / epidemiology | - |
dc.subject.MESH | Liver Neoplasms / ethnology | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease / epidemiology* | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease / ethnology | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Asian perspective on NAFLD-associated HCC | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Terry Cheuk-Fung Yip | - |
dc.contributor.googleauthor | Hye Won Lee | - |
dc.contributor.googleauthor | Wah Kheong Chan | - |
dc.contributor.googleauthor | Grace Lai-Hung Wong | - |
dc.contributor.googleauthor | Vincent Wai-Sun Wong | - |
dc.identifier.doi | 10.1016/j.jhep.2021.09.024 | - |
dc.contributor.localId | A03318 | - |
dc.relation.journalcode | J01441 | - |
dc.identifier.eissn | 1600-0641 | - |
dc.identifier.pmid | 34619251 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168827821020869 | - |
dc.subject.keyword | cirrhosis | - |
dc.subject.keyword | liver cancer | - |
dc.subject.keyword | liver fibrosis | - |
dc.subject.keyword | non-alcoholic fatty liver disease | - |
dc.subject.keyword | non-alcoholic steatohepatitis | - |
dc.contributor.alternativeName | Lee, Hye Won | - |
dc.contributor.affiliatedAuthor | 이혜원 | - |
dc.citation.volume | 76 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 726 | - |
dc.citation.endPage | 734 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HEPATOLOGY, Vol.76(3) : 726-734, 2022-03 | - |
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