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Asian perspective on NAFLD-associated HCC

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dc.contributor.author이혜원-
dc.date.accessioned2023-03-21T07:38:06Z-
dc.date.available2023-03-21T07:38:06Z-
dc.date.issued2022-03-
dc.identifier.issn0168-8278-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193479-
dc.description.abstractRecent data suggest that non-alcoholic fatty liver disease (NAFLD) has become a major public health problem in Asia, with an updated population prevalence of 34%. In parallel, NAFLD-associated hepatocellular carcinoma (HCC) is also on the rise. In this review, we describe the changing epidemiology of HCC in Asia over the past 30 years. While traditional risk factors for HCC (older age, male sex and metabolic factors) are also important in Asia, the PNPLA3 gene polymorphism is particularly prevalent in East Asia and may increase the risk of HCC. NAFLD among non-obese individuals is also commonly described in Asia. Because NAFLD is often undiagnosed, few patients receive HCC surveillance, and the target surveillance population beyond patients with cirrhosis remains poorly defined. As a result, NAFLD-associated HCC is often diagnosed at an advanced stage, rendering curative treatment impossible. Finally, despite around 20-30 years of universal vaccination, chronic HBV infection remains prevalent in Asia, and emerging evidence highlights the importance of metabolic factors and concomitant hepatic steatosis on HCC development in infected patients. Future studies should explore the role of metabolic treatments in HCC prevention among patients with hepatic steatosis and concomitant liver diseases.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAsia / epidemiology-
dc.subject.MESHAsia / ethnology-
dc.subject.MESHAsian People / ethnology-
dc.subject.MESHAsian People / statistics & numerical data*-
dc.subject.MESHCarcinoma, Hepatocellular / epidemiology*-
dc.subject.MESHCarcinoma, Hepatocellular / ethnology-
dc.subject.MESHDisease Progression-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms / epidemiology-
dc.subject.MESHLiver Neoplasms / ethnology-
dc.subject.MESHNon-alcoholic Fatty Liver Disease / epidemiology*-
dc.subject.MESHNon-alcoholic Fatty Liver Disease / ethnology-
dc.subject.MESHPrevalence-
dc.subject.MESHRisk Factors-
dc.titleAsian perspective on NAFLD-associated HCC-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorTerry Cheuk-Fung Yip-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorWah Kheong Chan-
dc.contributor.googleauthorGrace Lai-Hung Wong-
dc.contributor.googleauthorVincent Wai-Sun Wong-
dc.identifier.doi10.1016/j.jhep.2021.09.024-
dc.contributor.localIdA03318-
dc.relation.journalcodeJ01441-
dc.identifier.eissn1600-0641-
dc.identifier.pmid34619251-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0168827821020869-
dc.subject.keywordcirrhosis-
dc.subject.keywordliver cancer-
dc.subject.keywordliver fibrosis-
dc.subject.keywordnon-alcoholic fatty liver disease-
dc.subject.keywordnon-alcoholic steatohepatitis-
dc.contributor.alternativeNameLee, Hye Won-
dc.contributor.affiliatedAuthor이혜원-
dc.citation.volume76-
dc.citation.number3-
dc.citation.startPage726-
dc.citation.endPage734-
dc.identifier.bibliographicCitationJOURNAL OF HEPATOLOGY, Vol.76(3) : 726-734, 2022-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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