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Incidence of postoperative thrombotic events in ovarian cancer patients with a de-escalated prophylactic strategy: A retrospective cohort study

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dc.contributor.author김정철-
dc.contributor.author정영신-
dc.contributor.author김상운-
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author김유나-
dc.contributor.author남은지-
dc.contributor.author박준식-
dc.contributor.author이용재-
dc.contributor.author이정윤-
dc.date.accessioned2023-03-21T07:35:09Z-
dc.date.available2023-03-21T07:35:09Z-
dc.date.issued2022-04-
dc.identifier.issn0090-8258-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193456-
dc.description.abstractObjective: This study aimed to determine the incidence of thrombotic events in ovarian cancer patients following a de-escalated prophylactic strategy and to stratify risk groups. Methods: We reviewed the records of patients who underwent debulking surgery for ovarian cancer at a single institution between January 2007 and May 2019. We identified clinically diagnosed and radiologically confirmed cases of thrombotic events-classified as pulmonary thromboembolism (PE), deep vein thrombosis (DVT), and other thrombotic events-within 6 months of debulking surgery. Results: After excluding 13 patients diagnosed with thromboembolism at the baseline or during neoadjuvant chemotherapy, 799 were analyzed. Since the introduction of medical prophylaxis at our institution in 2009, 482 patients (60%) received medical prophylaxis with subcutaneous injection of low molecular weight heparin for 5 days with mechanical prophylaxis, whereas 317 (40%) received mechanical prophylaxis only. After debulking surgery, thrombotic events occurred in 28 patients (3.5%) including PE (n = 11), DVT (n = 10), and other thrombotic events (n = 7). Multivariable analysis identified age, body mass index (BMI), and operative duration as independent risk factors associated with thrombotic events. A thrombotic event was an independent prognostic factor for overall survival (HR 2.17, 95% CI 1.16-4.1). A cut-off analysis for pre-operative identifiable risk factors showed age < 57 years and BMI < 21 could help define low-risk groups. One patient from 172 low-risk patients (0.58%) experienced a thrombotic event. Conclusions: The thrombotic event incidence was low in our cohort. A de-escalated prophylaxis strategy may be considered in young (age < 57 years) and lean (BMI < 21) patients.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAcademic Press-
dc.relation.isPartOfGYNECOLOGIC ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnticoagulants / therapeutic use-
dc.subject.MESHCarcinoma, Ovarian Epithelial / drug therapy-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOvarian Neoplasms* / drug therapy-
dc.subject.MESHPostoperative Complications / epidemiology-
dc.subject.MESHPostoperative Complications / etiology-
dc.subject.MESHPostoperative Complications / prevention & control-
dc.subject.MESHPulmonary Embolism*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHVenous Thrombosis* / epidemiology-
dc.subject.MESHVenous Thrombosis* / etiology-
dc.subject.MESHVenous Thrombosis* / prevention & control-
dc.titleIncidence of postoperative thrombotic events in ovarian cancer patients with a de-escalated prophylactic strategy: A retrospective cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorYoo-Na Kim-
dc.contributor.googleauthorJung Chul Kim-
dc.contributor.googleauthorYoung Shin Chung-
dc.contributor.googleauthorJunsik Park-
dc.contributor.googleauthorYong Jae Lee-
dc.contributor.googleauthorJung-Yun Lee-
dc.contributor.googleauthorEun Ji Nam-
dc.contributor.googleauthorSang Wun Kim-
dc.contributor.googleauthorSunghoon Kim-
dc.contributor.googleauthorYoung Tae Kim-
dc.identifier.doi10.1016/j.ygyno.2022.02.007-
dc.contributor.localIdA06385-
dc.contributor.localIdA04849-
dc.contributor.localIdA00526-
dc.contributor.localIdA00595-
dc.contributor.localIdA00729-
dc.contributor.localIdA05561-
dc.contributor.localIdA01262-
dc.contributor.localIdA05788-
dc.contributor.localIdA05165-
dc.contributor.localIdA04638-
dc.relation.journalcodeJ00956-
dc.identifier.eissn1095-6859-
dc.identifier.pmid35216810-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0090825822000919-
dc.subject.keywordDe-escalation-
dc.subject.keywordOvarian neoplasms-
dc.subject.keywordProphylaxis-
dc.subject.keywordVenous thrombosis-
dc.contributor.alternativeNameKim, Jung Chul-
dc.contributor.affiliatedAuthor김정철-
dc.contributor.affiliatedAuthor정영신-
dc.contributor.affiliatedAuthor김상운-
dc.contributor.affiliatedAuthor김성훈-
dc.contributor.affiliatedAuthor김영태-
dc.contributor.affiliatedAuthor김유나-
dc.contributor.affiliatedAuthor남은지-
dc.contributor.affiliatedAuthor박준식-
dc.contributor.affiliatedAuthor이용재-
dc.contributor.affiliatedAuthor이정윤-
dc.citation.volume165-
dc.citation.number1-
dc.citation.startPage75-
dc.citation.endPage81-
dc.identifier.bibliographicCitationGYNECOLOGIC ONCOLOGY, Vol.165(1) : 75-81, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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