Cited 4 times in
Sex-Differential Associations Between Body Mass Index and the Incidence of Dementia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2023-03-21T07:33:15Z | - |
dc.date.available | 2023-03-21T07:33:15Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193432 | - |
dc.description.abstract | Background: Little is known about the sex differences in the association between body mass index (BMI) and dementia in late life. Objective: Therefore, this retrospective cohort study aimed to analyze associations between BMI and dementia in older women and men separately in general practices in Germany. Methods: This study included patients followed in one of 832 general practices in Germany between 2006 and 2019 (index date: first visit date). Study variables included dementia (dependent variable), BMI (independent variable), age, sex, and comorbidities (control variables). Kaplan-Meier curves and adjusted Cox regression analyses were conducted to analyze associations between BMI and the 10-year incidence of dementia in women and men, separately. Results: There were 296,767 patients included in this study (mean [standard deviation] age 70.2 [5.9] years; 54.3% women). The proportion of underweight, normal weight, overweight, and obesity was 0.9%, 25.5%, 41.5%, and 32.1%, respectively. The 10-year incidence of dementia significantly decreased with increasing BMI, from 11.5% in women with underweight to 9.1% in those with obesity (log-rank p < 0.001). Respective figures in men were 12.0% and 8.2% (log-rank p < 0.001). In women, only overweight (versus normal weight) was significantly associated with dementia (HR = 0.93, 95% CI = 0.88-0.97). In contrast, in men, the only BMI category significantly associated with the incidence of dementia was underweight (HR = 1.58, 95% CI = 1.11-2.25). Conclusion: In this study conducted in Germany, overweight was negatively associated with dementia in women, whereas there was a positive underweight-dementia relationship in men. More data are needed to confirm or refute these findings in other settings. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | IOS Press | - |
dc.relation.isPartOf | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Dementia* / complications | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Obesity* / complications | - |
dc.subject.MESH | Obesity* / epidemiology | - |
dc.subject.MESH | Overweight* / complications | - |
dc.subject.MESH | Overweight* / epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sex Factors* | - |
dc.subject.MESH | Thinness* / complications | - |
dc.subject.MESH | Thinness* / epidemiology | - |
dc.title | Sex-Differential Associations Between Body Mass Index and the Incidence of Dementia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Louis Jacob | - |
dc.contributor.googleauthor | Lee Smith | - |
dc.contributor.googleauthor | Ai Koyanagi | - |
dc.contributor.googleauthor | Marcel Konrad | - |
dc.contributor.googleauthor | Josep Maria Haro | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Karel Kostev | - |
dc.identifier.doi | 10.3233/JAD-220147 | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J01231 | - |
dc.identifier.eissn | 1875-8908 | - |
dc.identifier.pmid | 35662122 | - |
dc.identifier.url | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad220147 | - |
dc.subject.keyword | Body mass index | - |
dc.subject.keyword | Germany | - |
dc.subject.keyword | dementia | - |
dc.subject.keyword | retrospective cohort study | - |
dc.subject.keyword | sex differences | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.citation.volume | 88 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 631 | - |
dc.citation.endPage | 639 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALZHEIMERS DISEASE, Vol.88(2) : 631-639, 2022-07 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.