Cited 7 times in
Effect of Dapagliflozin in Combination with Lobeglitazone and Metformin in Korean Patients with Type 2 Diabetes in Real-World Clinical Practice
DC Field | Value | Language |
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dc.contributor.author | 이용호 | - |
dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2023-03-21T07:30:04Z | - |
dc.date.available | 2023-03-21T07:30:04Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193406 | - |
dc.description.abstract | Purpose: This study aimed to evaluate the efficacy and tolerability of dapagliflozin as an add-on or a switch therapy to lobeglitazone plus metformin (MFM) in Korean patients with inadequately controlled type 2 diabetes mellitus (T2DM) in real-world clinical practice. Materials and methods: The study included 109 patients who started dapagliflozin as add-on or switch therapy to lobeglitazone plus MFM. The primary outcome was a change in glycated hemoglobin (HbA1c) level from baseline after 12 months of treatment. Secondary outcomes included changes in fasting plasma glucose (FPG), lipid profiles, body weight, visceral fat area (VFA), and blood pressure after 12 months of treatment. Results: The baseline HbA1c was 8.3±1.3% (8.7±1.5% in the add-on group and 8.1±1.0% in the switch group). After 12 months, mean HbA1c decreased (-0.91%) in all patients (p<0.05) (-1.39% in the add-on group and -0.63% in the switch group). Significant reductions in FPG were also observed in both the add-on and switch groups (-54.37 mg/dL and -24.68 mg/dL, respectively). Overall, there was a significant improvement in serum triglyceride (-24.74 mg/dL), low density lipoprotein cholesterol (-7.92 mg/dL), body weight (-2.98 kg), VFA (-9.00 cm²), and systolic blood pressure (-8.67 mm Hg). Approximately 35.8% of patients achieved HbA1c <7.0% after 12 months. Conclusion: Dapagliflozin, as an add-on or a switch therapy to lobeglitazone plus MFM, can be a suitable alternative for Korean patients with inadequately controlled T2DM. The combination therapy resulted in significant reductions in HbA1c levels, body weight, and blood pressure. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Benzhydryl Compounds | - |
dc.subject.MESH | Blood Glucose | - |
dc.subject.MESH | Body Weight | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Glucosides | - |
dc.subject.MESH | Glycated Hemoglobin | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoglycemic Agents | - |
dc.subject.MESH | Metformin* | - |
dc.subject.MESH | Pyrimidines | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Thiazolidinediones | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Effect of Dapagliflozin in Combination with Lobeglitazone and Metformin in Korean Patients with Type 2 Diabetes in Real-World Clinical Practice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Da Hea Seo | - |
dc.contributor.googleauthor | Young Ju Suh | - |
dc.contributor.googleauthor | Yongin Cho | - |
dc.contributor.googleauthor | Seong Hee Ahn | - |
dc.contributor.googleauthor | Seongha Seo | - |
dc.contributor.googleauthor | Seongbin Hong | - |
dc.contributor.googleauthor | Yong-Ho Lee | - |
dc.contributor.googleauthor | Young Ju Choi | - |
dc.contributor.googleauthor | Eunjig Lee | - |
dc.contributor.googleauthor | So Hun Kim | - |
dc.identifier.doi | 10.3349/ymj.2022.63.9.825 | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A03050 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 36031782 | - |
dc.subject.keyword | Diabetes mellitus, type 2 | - |
dc.subject.keyword | sodium-glucose transporter 2 inhibitors | - |
dc.subject.keyword | thiozolidinediones | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | 이용호 | - |
dc.contributor.affiliatedAuthor | 이은직 | - |
dc.citation.volume | 63 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 825 | - |
dc.citation.endPage | 833 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.63(9) : 825-833, 2022-09 | - |
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