Cited 7 times in
Serum creatinine to cystatin C ratio and clinical outcomes in adults with non-dialysis chronic kidney disease
DC Field | Value | Language |
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dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2023-03-21T07:26:45Z | - |
dc.date.available | 2023-03-21T07:26:45Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193380 | - |
dc.description.abstract | Background: Studies have suggested that the serum creatinine/cystatin C (Cr/CysC) ratio is a surrogate marker for muscle wasting is associated with adverse outcomes in several disease conditions. To clarify the utility of the Cr/CysC ratio as a prognostic marker in chronic kidney disease (CKD) we evaluated the association between the Cr/CysC ratio clinical outcomes in patients with non-dialysis CKD. Methods: This prospective observational cohort study included 1,966 participants of the KoreaN cohort study Outcomes in patients With CKD (KNOW-CKD). We evaluated associated factors with the serum Cr/CysC ratio and association between the serum Cr/CysC ratio and composite outcomes of all-cause death and cardiovascular events (CVEs). Results: The mean age was 54 ± 12 (SD) years and 61% were men. The mean serum Cr/CysC ratio was 10.97 ± 1.94 in men and 9.10 ± 1.77 in women. The Cr/CysC ratio correlated positively with urinary creatinine excretion, a marker of muscle mass. In the fully adjusted Cox proportional hazard model, the Cr/CysC ratio was associated with the occurrence of adverse outcomes through a median follow-up of 5.9 years [hazard ratio (HR) = 0.92, 95% confidence interval (CI) = 0.85-0.99 for the composite outcomes, HR = 0.87, 95% CI, 0.78 - 0.97 for all-cause death, and HR = 0.93; 95% CI, 0.84-1.04 for CVEs]. In subgroup analyses, there were interactions of the Cr/CysC ratio with age and sex for risk of the clinical outcomes, but not eGFR group. Conclusion: A higher Cr/CysC ratio is associated with a lower risk of the composite outcomes, especially all-cause mortality, even after adjusting for eGFR. These suggest that the Cr/CysC ratio is a useful prognostic marker in CKD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Media S.A. | - |
dc.relation.isPartOf | FRONTIERS IN NUTRITION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Serum creatinine to cystatin C ratio and clinical outcomes in adults with non-dialysis chronic kidney disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Young Youl Hyun | - |
dc.contributor.googleauthor | Kyu-Beck Lee | - |
dc.contributor.googleauthor | Hyoungnae Kim | - |
dc.contributor.googleauthor | Yaeni Kim | - |
dc.contributor.googleauthor | Wookyung Chung | - |
dc.contributor.googleauthor | Hayne Cho Park | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Yun Kyu Oh | - |
dc.contributor.googleauthor | Sue Kyung Park | - |
dc.contributor.googleauthor | Kook-Hwan Oh | - |
dc.identifier.doi | 10.3389/fnut.2022.996674 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J04192 | - |
dc.identifier.eissn | 2296-861X | - |
dc.identifier.pmid | 36225865 | - |
dc.subject.keyword | cardiovascular events | - |
dc.subject.keyword | chronic kidney disease | - |
dc.subject.keyword | creatinine/cystatin C ratio | - |
dc.subject.keyword | death | - |
dc.subject.keyword | muscle wasting | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 9 | - |
dc.citation.startPage | 996674 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN NUTRITION, Vol.9 : 996674, 2022-09 | - |
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