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Effect of low skeletal muscle mass and sarcopenic obesity on chronic kidney disease in patients with type 2 diabetes

 Da Hea Seo  ;  Young Ju Suh  ;  Yongin Cho  ;  Seong Hee Ahn  ;  Seongha Seo  ;  Seongbin Hong  ;  Yong-Ho Lee  ;  Young Ju Choi  ;  Eunjig Lee  ;  So Hun Kim 
 OBESITY, Vol.30(10) : 2034-2043, 2022-10 
Journal Title
Issue Date
Diabetes Mellitus, Type 2* / complications ; Diabetes Mellitus, Type 2* / epidemiology ; Female ; Humans ; Male ; Muscle, Skeletal ; Obesity / complications ; Renal Insufficiency, Chronic* / complications ; Renal Insufficiency, Chronic* / epidemiology ; Risk Factors ; Sarcopenia* / complications ; Sarcopenia* / epidemiology
Objective: This study aimed to investigate the association between low muscle mass or sarcopenic obesity and the risk of incident chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 3123 patients with T2DM with preserved renal function were followed up for incident CKD. Skeletal muscle mass was estimated from bioelectrical impedance analysis. CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 . Sarcopenic obesity was defined as the coexistence of sarcopenia and abdominal obesity.

Results: During 8.9 years of follow-up, 530 (17.0%) patients developed incident CKD. When patients were divided into three groups based on sex-specific tertiles, lower muscle mass was not associated with an increased risk of incident CKD after adjustment for risk factors. However, when patients were divided into four groups according to the presence of sarcopenia and obesity, sarcopenic obesity was associated with an increased risk of incident CKD (adjusted hazard ratio 1.77; 95% CI: 1.24-2.51; p = 0.001) compared with the other groups.

Conclusions: Sarcopenic obesity, but not low muscle mass alone, may increase the risk of CKD in patients with T2DM.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
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