Cited 4 times in
Early versus late acute coronary syndrome risk patterns of coronary atherosclerotic plaque
DC Field | Value | Language |
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dc.contributor.author | 이상은 | - |
dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2023-03-21T07:25:35Z | - |
dc.date.available | 2023-03-21T07:25:35Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 2047-2404 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193367 | - |
dc.description.abstract | Aims: The temporal instability of coronary atherosclerotic plaque preceding an incident acute coronary syndrome (ACS) is not well defined. We sought to examine differences in the volume and composition of coronary atherosclerosis between patients experiencing an early (≤90 days) versus late ACS (>90 days) after baseline coronary computed tomography angiography (CCTA). Methods and results: From a multicenter study, we enrolled patients who underwent a clinically indicated baseline CCTA and experienced ACS during follow-up. Separate core laboratories performed blinded adjudication of ACS events and quantification of CCTA including compositional plaque volumes by Hounsfield units (HU): calcified plaque >350 HU, fibrous plaque 131-350 HU, fibrofatty plaque 31-130 HU and necrotic core <30 HU. In 234 patients (mean age 62 ± 12 years, 36% women), early and late ACS occurred in 129 and 105 patients after a mean of 395 ± 622 days, respectively. Patients with early ACS had a greater maximal diameter stenosis and maximal cross-sectional plaque burden as compared to patients with late ACS (P < 0.05). Larger total, fibrous, fibrofatty, and necrotic core volumes were observed in the early ACS group (P < 0.05). Findings for total, fibrous, fibrofatty, and necrotic core volumes were reproduced in an external validation cohort (P < 0.05). Conclusions: Volumetric differences in composition of coronary atherosclerosis exist between ACS patients according to their timing antecedent to the acute event. These data support that a large burden of non-calcified plaque on CCTA is strongly associated with near-term plaque instability and ACS risk. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acute Coronary Syndrome* / diagnostic imaging | - |
dc.subject.MESH | Acute Coronary Syndrome* / epidemiology | - |
dc.subject.MESH | Acute Coronary Syndrome* / etiology | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Computed Tomography Angiography | - |
dc.subject.MESH | Coronary Angiography / methods | - |
dc.subject.MESH | Coronary Artery Disease* / complications | - |
dc.subject.MESH | Coronary Artery Disease* / diagnostic imaging | - |
dc.subject.MESH | Coronary Artery Disease* / epidemiology | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Plaque, Atherosclerotic* / complications | - |
dc.subject.MESH | Plaque, Atherosclerotic* / diagnostic imaging | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.title | Early versus late acute coronary syndrome risk patterns of coronary atherosclerotic plaque | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Inge J van den Hoogen | - |
dc.contributor.googleauthor | Wijnand J Stuijfzand | - |
dc.contributor.googleauthor | Umberto Gianni | - |
dc.contributor.googleauthor | Alexander R van Rosendael | - |
dc.contributor.googleauthor | A Maxim Bax | - |
dc.contributor.googleauthor | Yao Lu | - |
dc.contributor.googleauthor | Sara W Tantawy | - |
dc.contributor.googleauthor | Emma J Hollenberg | - |
dc.contributor.googleauthor | Daniele Andreini | - |
dc.contributor.googleauthor | Mouaz H Al-Mallah | - |
dc.contributor.googleauthor | Filippo Cademartiri | - |
dc.contributor.googleauthor | Kavitha Chinnaiyan | - |
dc.contributor.googleauthor | Benjamin J W Chow | - |
dc.contributor.googleauthor | Edoardo Conte | - |
dc.contributor.googleauthor | Ricardo C Cury | - |
dc.contributor.googleauthor | Gudrun Feuchtner | - |
dc.contributor.googleauthor | Pedro de Araújo Gonçalves | - |
dc.contributor.googleauthor | Martin Hadamitzky | - |
dc.contributor.googleauthor | Yong Jin Kim | - |
dc.contributor.googleauthor | Jonathon Leipsic | - |
dc.contributor.googleauthor | Erica Maffei | - |
dc.contributor.googleauthor | Hugo Marques | - |
dc.contributor.googleauthor | Fabian Plank | - |
dc.contributor.googleauthor | Gianluca Pontone | - |
dc.contributor.googleauthor | Todd C Villines | - |
dc.contributor.googleauthor | Sang Eun Lee | - |
dc.contributor.googleauthor | Subhi J Al'Aref | - |
dc.contributor.googleauthor | Lohendran Baskaran | - |
dc.contributor.googleauthor | Ibrahim Danad | - |
dc.contributor.googleauthor | Heidi Gransar | - |
dc.contributor.googleauthor | Matthew J Budoff | - |
dc.contributor.googleauthor | Habib Samady | - |
dc.contributor.googleauthor | Renu Virmani | - |
dc.contributor.googleauthor | Daniel S Berman | - |
dc.contributor.googleauthor | Hyuk Jae Chang | - |
dc.contributor.googleauthor | Jagat Narula | - |
dc.contributor.googleauthor | James K Min | - |
dc.contributor.googleauthor | Jeroen J Bax | - |
dc.contributor.googleauthor | Fay Y Lin | - |
dc.contributor.googleauthor | Leslee J Shaw | - |
dc.contributor.googleauthor | ICONIC Investigators | - |
dc.identifier.doi | 10.1093/ehjci/jeac114 | - |
dc.contributor.localId | A02827 | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J00806 | - |
dc.identifier.eissn | 2047-2412 | - |
dc.identifier.pmid | 35904766 | - |
dc.identifier.url | https://academic.oup.com/ehjcimaging/article/23/10/1314/6651864 | - |
dc.subject.keyword | acute coronary syndrome | - |
dc.subject.keyword | atherosclerosis | - |
dc.subject.keyword | coronary artery disease | - |
dc.subject.keyword | coronary computed tomography angiography | - |
dc.contributor.alternativeName | Lee, Sang-Eun | - |
dc.contributor.affiliatedAuthor | 이상은 | - |
dc.contributor.affiliatedAuthor | 장혁재 | - |
dc.citation.volume | 23 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1314 | - |
dc.citation.endPage | 1323 | - |
dc.identifier.bibliographicCitation | EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol.23(10) : 1314-1323, 2022-10 | - |
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