Cited 1 times in
Aberrant DNA Methylation Maker for Predicting Metachronous Recurrence After Endoscopic Resection of Gastric Neoplasm
DC Field | Value | Language |
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dc.contributor.author | 최윤진 | - |
dc.date.accessioned | 2023-03-21T07:25:27Z | - |
dc.date.available | 2023-03-21T07:25:27Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193365 | - |
dc.description.abstract | Purpose: This study aimed to investigate whether MOS methylation can be useful for the prediction of metachronous recurrence after endoscopic resection of gastric neoplasms. Materials and methods: From 2012 to 2017, 294 patients were prospectively enrolled after endoscopic resection of gastric dysplasia (n=171) or early gastric cancer (n=123). When Helicobacter pylori was positive, eradication therapy was performed. Among them, 124 patients completed the study protocol (follow-up duration > 3 years or development of metachronous recurrence during the follow-up). Methylation levels of MOS were measured at baseline using quantitative MethyLight assay from the antrum. Results: Median follow-up duration was 49.9 months. MOS methylation levels at baseline were not different by age, sex, and current H. pylorii infection, but they showed a weak correlation with operative link on gastritis assessment (OLGA) or operative link on gastric intestinal metaplasia assessment (OLGIM) stages (Spearman's ρ=0.240 and 0.174, respectively; p < 0.05). During the follow-up, a total of 20 metachronous gastric neoplasms (13 adenomas and 7 adenocarcinomas) were developed. Either OLGA or OLGIM stage was not useful in predicting the risk for metachronous recurrence. In contrast, MOS methylation high group (≥ 34.82%) had a significantly increased risk for metachronous recurrence compared to MOS methylation low group (adjusted hazard ratio, 4.76; 95% confidence interval, 1.54 to 14.79; p=0.007). Conclusion: MOS methylation can be a promising marker for predicting metachronous recurrence after endoscopic resection of gastric neoplasms. To confirm the usefulness of MOS methylation, validation studies are warranted in the future (ClinicalTrials No. NCT04830618). | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | DNA Methylation | - |
dc.subject.MESH | Gastroscopy / adverse effects | - |
dc.subject.MESH | Helicobacter Infections* / complications | - |
dc.subject.MESH | Helicobacter Infections* / diagnosis | - |
dc.subject.MESH | Helicobacter Infections* / genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neoplasms, Second Primary* / diagnosis | - |
dc.subject.MESH | Neoplasms, Second Primary* / genetics | - |
dc.subject.MESH | Neoplasms, Second Primary* / surgery | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Stomach Neoplasms* / diagnosis | - |
dc.subject.MESH | Stomach Neoplasms* / genetics | - |
dc.subject.MESH | Stomach Neoplasms* / surgery | - |
dc.title | Aberrant DNA Methylation Maker for Predicting Metachronous Recurrence After Endoscopic Resection of Gastric Neoplasm | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Cheol Min Shin | - |
dc.contributor.googleauthor | Nayoung Kim | - |
dc.contributor.googleauthor | Hyuk Yoon | - |
dc.contributor.googleauthor | Yoon Jin Choi | - |
dc.contributor.googleauthor | Ji Hyun Park | - |
dc.contributor.googleauthor | Young Soo Park | - |
dc.contributor.googleauthor | Dong Ho Lee | - |
dc.identifier.doi | 10.4143/crt.2021.997 | - |
dc.contributor.localId | A05984 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 35038821 | - |
dc.subject.keyword | Methylation | - |
dc.subject.keyword | Recurrence | - |
dc.subject.keyword | Second primary neoplasms | - |
dc.subject.keyword | Stomach neoplasms | - |
dc.contributor.alternativeName | Choi, Yoon Jin | - |
dc.contributor.affiliatedAuthor | 최윤진 | - |
dc.citation.volume | 54 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1157 | - |
dc.citation.endPage | 1166 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.54(4) : 1157-1166, 2022-10 | - |
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