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Optimal office blood pressure levels in younger ( <50 years old) Korean hypertensive patients: a nationwide cohort study in South Korea
DC Field | Value | Language |
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dc.contributor.author | 김민관 | - |
dc.date.accessioned | 2023-03-21T07:20:14Z | - |
dc.date.available | 2023-03-21T07:20:14Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 0263-6352 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193317 | - |
dc.description.abstract | Background: It is unclear what thresholds and targets of office blood pressure (BP) for treatment are appropriate in younger (<50 years old) hypertensive patients. Thus, the aim of this study was to evaluate associations of office BP levels with major cardiovascular events (MACEs) in these patients. Methods: Using the Korean National Health Insurance Service database, data of 98 192 younger (<50 years old) hypertensive patients having BP measurements available without any history of cardiovascular events from 2002 to 2011 were extracted. This cohort study evaluated associations of BP levels (<120/<70, 120-129/70-79, 130-139/80-89, 140-149/90-99, and ≥150/≥100 mmHg) with MACEs. The study outcome was MACE, a composite of cardiovascular death, myocardial infarction, stroke, and heart failure. Results: In all patients, those treated with antihypertensive medication accounted for 34.7% and those who achieved BP less than 130/80 mmHg accounted for 35.5%. During a mean follow-up of 9.5 ± 2.8 years, 4918 (5%) MACEs were documented in our cohort. The risk of MACE was the lowest [adjusted hazard ratio: 0.77, 95% confidence interval (CI) 0.66-0.89] for those with BP level of less than 120/less than 70 mmHg. It was the highest (hazard ratio 2.0, 95% CI 1.83-2.19) for those with BP level of at least 150/at least 100 mmHg in comparison with those with BP level of 130-139/80-89 mmHg. These results were consistent for all age groups (20-29, 30-39, and 40-49 years) and both sexes. Conclusion: Elevated BP level from less than 120 mmHg/less than 70 mmHg is significantly correlated with an increased risk of MACE in younger (<50 years old) Korean hypertensive patients. Lowering BP to less than 120 mmHg/less than 70 mmHg is needed for these patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | JOURNAL OF HYPERTENSION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antihypertensive Agents / therapeutic use | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Blood Pressure Determination | - |
dc.subject.MESH | Cardiovascular Diseases* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Young Adult | - |
dc.title | Optimal office blood pressure levels in younger ( <50 years old) Korean hypertensive patients: a nationwide cohort study in South Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Chang Hee Kwon | - |
dc.contributor.googleauthor | Hae-Young Lee | - |
dc.contributor.googleauthor | Jun Hyeok Lee | - |
dc.contributor.googleauthor | Minkwan Kim | - |
dc.contributor.googleauthor | Ki-Chul Sung | - |
dc.identifier.doi | 10.1097/HJH.0000000000003277 | - |
dc.contributor.localId | A00482 | - |
dc.relation.journalcode | J01448 | - |
dc.identifier.eissn | 1473-5598 | - |
dc.identifier.pmid | 35983871 | - |
dc.identifier.url | https://journals.lww.com/jhypertension/Fulltext/2022/12000/Optimal_office_blood_pressure_levels_in_younger.12.aspx | - |
dc.citation.volume | 40 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2449 | - |
dc.citation.endPage | 2458 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HYPERTENSION, Vol.40(12) : 2449-2458, 2022-12 | - |
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