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Regrowth factors of WHO grade I skull base meningiomas following incomplete resection

DC Field Value Language
dc.contributor.author김세훈-
dc.contributor.author박현호-
dc.contributor.author유지환-
dc.contributor.author이규성-
dc.contributor.author차윤진-
dc.contributor.author홍창기-
dc.date.accessioned2023-03-10T01:38:22Z-
dc.date.available2023-03-10T01:38:22Z-
dc.date.issued2022-12-
dc.identifier.issn0022-3085-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193267-
dc.description.abstractObjective: The role of adjuvant radiation therapy following incomplete resection of WHO grade I skull base meningiomas (SBMs) is controversial, and little is known regarding the behavior of residual tumors. The authors investigated the factors that influence regrowth of residual WHO grade I SBMs following incomplete resection. Methods: From 2005 to 2019, a total of 710 patients underwent surgery for newly diagnosed WHO grade I SBMs. The data of 115 patients (16.2%) with incomplete resection and without any adjuvant radiotherapy were retrospectively assessed during a mean follow-up of 78 months (range 27-198 months). Pre-, intra-, and postoperative clinical and molecular factors were analyzed for relevance to regrowth-free survival (RFS). Results: Eighty patients were eligible for analysis, excluding those who were lost to follow-up (n = 10) or had adjuvant radiotherapy (n = 25). Regrowth occurred in 39 patients (48.7%), with a mean RFS of 50 months (range 3-191 months). Significant predictors of regrowth were Ki-67 proliferative index (PI) ≥ 4% (p = 0.017), Simpson resection grades IV and V (p = 0.005), and invasion of the cavernous sinus (p = 0.027) and Meckel's cave (p = 0.027). After Cox regression analysis, only Ki-67 PI ≥ 4% (hazard ratio [HR] 9.39, p = 0.003) and Simpson grades IV and V (HR 8.65, p = 0.001) showed significant deterioration of RFS. When stratified into 4 scoring groups, the mean RFSs were 110, 70, 38, and 9 months for scores 1 (Ki-67 PI < 4% and Simpson grade III), 2 (Ki-67 PI < 4% and Simpson grades IV and V), 3 (Ki-67 PI ≥ 4% and Simpson grade III), and 4 (Ki-67 PI ≥ 4% and Simpson grades IV and V), respectively. RFS was significantly longer for score 1 versus scores 2-4 (p < 0.01). Tumor consistency, histology, location, peritumoral edema, vascular encasement, and telomerase reverse transcriptase promoter mutation had no impact on regrowth. Conclusions: Ki-67 PI and Simpson resection grade showed significant associations with RFS for WHO grade I SBMs following incomplete resection. Ki-67 PI and Simpson resection grade could be utilized to stratify the level of risk for regrowth.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Association of Neurological Surgeons-
dc.relation.isPartOfJOURNAL OF NEUROSURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHHumans-
dc.subject.MESHKi-67 Antigen-
dc.subject.MESHMeningeal Neoplasms* / diagnosis-
dc.subject.MESHMeningeal Neoplasms* / radiotherapy-
dc.subject.MESHMeningeal Neoplasms* / surgery-
dc.subject.MESHMeningioma* / diagnosis-
dc.subject.MESHMeningioma* / radiotherapy-
dc.subject.MESHMeningioma* / surgery-
dc.subject.MESHNeoplasm Recurrence, Local / surgery-
dc.subject.MESHNeurosurgical Procedures-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSkull Base / surgery-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHWorld Health Organization-
dc.titleRegrowth factors of WHO grade I skull base meningiomas following incomplete resection-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorHun Ho Park-
dc.contributor.googleauthorJihwan Yoo-
dc.contributor.googleauthorHyeong-Cheol Oh-
dc.contributor.googleauthorYoon Jin Cha-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorChang-Ki Hong-
dc.contributor.googleauthorKyu-Sung Lee-
dc.identifier.doi10.3171/2022.3.JNS2299-
dc.contributor.localIdA00610-
dc.contributor.localIdA01750-
dc.contributor.localIdA05158-
dc.contributor.localIdA02682-
dc.contributor.localIdA04001-
dc.contributor.localIdA04445-
dc.relation.journalcodeJ01636-
dc.identifier.eissn1933-0693-
dc.identifier.pmid35453107-
dc.identifier.urlhttps://thejns.org/view/journals/j-neurosurg/137/6/article-p1656.xml-
dc.subject.keywordWHO grade I-
dc.subject.keywordincomplete resection-
dc.subject.keywordnatural behavior-
dc.subject.keywordoncology-
dc.subject.keywordregrowth-
dc.subject.keywordresidual tumor-
dc.subject.keywordskull base meningioma-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.affiliatedAuthor김세훈-
dc.contributor.affiliatedAuthor박현호-
dc.contributor.affiliatedAuthor유지환-
dc.contributor.affiliatedAuthor이규성-
dc.contributor.affiliatedAuthor차윤진-
dc.contributor.affiliatedAuthor홍창기-
dc.citation.volume137-
dc.citation.number6-
dc.citation.startPage1656-
dc.citation.endPage1665-
dc.identifier.bibliographicCitationJOURNAL OF NEUROSURGERY, Vol.137(6) : 1656-1665, 2022-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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