Cited 4 times in
Regrowth factors of WHO grade I skull base meningiomas following incomplete resection
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 박현호 | - |
dc.contributor.author | 유지환 | - |
dc.contributor.author | 이규성 | - |
dc.contributor.author | 차윤진 | - |
dc.contributor.author | 홍창기 | - |
dc.date.accessioned | 2023-03-10T01:38:22Z | - |
dc.date.available | 2023-03-10T01:38:22Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 0022-3085 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193267 | - |
dc.description.abstract | Objective: The role of adjuvant radiation therapy following incomplete resection of WHO grade I skull base meningiomas (SBMs) is controversial, and little is known regarding the behavior of residual tumors. The authors investigated the factors that influence regrowth of residual WHO grade I SBMs following incomplete resection. Methods: From 2005 to 2019, a total of 710 patients underwent surgery for newly diagnosed WHO grade I SBMs. The data of 115 patients (16.2%) with incomplete resection and without any adjuvant radiotherapy were retrospectively assessed during a mean follow-up of 78 months (range 27-198 months). Pre-, intra-, and postoperative clinical and molecular factors were analyzed for relevance to regrowth-free survival (RFS). Results: Eighty patients were eligible for analysis, excluding those who were lost to follow-up (n = 10) or had adjuvant radiotherapy (n = 25). Regrowth occurred in 39 patients (48.7%), with a mean RFS of 50 months (range 3-191 months). Significant predictors of regrowth were Ki-67 proliferative index (PI) ≥ 4% (p = 0.017), Simpson resection grades IV and V (p = 0.005), and invasion of the cavernous sinus (p = 0.027) and Meckel's cave (p = 0.027). After Cox regression analysis, only Ki-67 PI ≥ 4% (hazard ratio [HR] 9.39, p = 0.003) and Simpson grades IV and V (HR 8.65, p = 0.001) showed significant deterioration of RFS. When stratified into 4 scoring groups, the mean RFSs were 110, 70, 38, and 9 months for scores 1 (Ki-67 PI < 4% and Simpson grade III), 2 (Ki-67 PI < 4% and Simpson grades IV and V), 3 (Ki-67 PI ≥ 4% and Simpson grade III), and 4 (Ki-67 PI ≥ 4% and Simpson grades IV and V), respectively. RFS was significantly longer for score 1 versus scores 2-4 (p < 0.01). Tumor consistency, histology, location, peritumoral edema, vascular encasement, and telomerase reverse transcriptase promoter mutation had no impact on regrowth. Conclusions: Ki-67 PI and Simpson resection grade showed significant associations with RFS for WHO grade I SBMs following incomplete resection. Ki-67 PI and Simpson resection grade could be utilized to stratify the level of risk for regrowth. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Association of Neurological Surgeons | - |
dc.relation.isPartOf | JOURNAL OF NEUROSURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ki-67 Antigen | - |
dc.subject.MESH | Meningeal Neoplasms* / diagnosis | - |
dc.subject.MESH | Meningeal Neoplasms* / radiotherapy | - |
dc.subject.MESH | Meningeal Neoplasms* / surgery | - |
dc.subject.MESH | Meningioma* / diagnosis | - |
dc.subject.MESH | Meningioma* / radiotherapy | - |
dc.subject.MESH | Meningioma* / surgery | - |
dc.subject.MESH | Neoplasm Recurrence, Local / surgery | - |
dc.subject.MESH | Neurosurgical Procedures | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Skull Base / surgery | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | World Health Organization | - |
dc.title | Regrowth factors of WHO grade I skull base meningiomas following incomplete resection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Hun Ho Park | - |
dc.contributor.googleauthor | Jihwan Yoo | - |
dc.contributor.googleauthor | Hyeong-Cheol Oh | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Chang-Ki Hong | - |
dc.contributor.googleauthor | Kyu-Sung Lee | - |
dc.identifier.doi | 10.3171/2022.3.JNS2299 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A01750 | - |
dc.contributor.localId | A05158 | - |
dc.contributor.localId | A02682 | - |
dc.contributor.localId | A04001 | - |
dc.contributor.localId | A04445 | - |
dc.relation.journalcode | J01636 | - |
dc.identifier.eissn | 1933-0693 | - |
dc.identifier.pmid | 35453107 | - |
dc.identifier.url | https://thejns.org/view/journals/j-neurosurg/137/6/article-p1656.xml | - |
dc.subject.keyword | WHO grade I | - |
dc.subject.keyword | incomplete resection | - |
dc.subject.keyword | natural behavior | - |
dc.subject.keyword | oncology | - |
dc.subject.keyword | regrowth | - |
dc.subject.keyword | residual tumor | - |
dc.subject.keyword | skull base meningioma | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | 김세훈 | - |
dc.contributor.affiliatedAuthor | 박현호 | - |
dc.contributor.affiliatedAuthor | 유지환 | - |
dc.contributor.affiliatedAuthor | 이규성 | - |
dc.contributor.affiliatedAuthor | 차윤진 | - |
dc.contributor.affiliatedAuthor | 홍창기 | - |
dc.citation.volume | 137 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1656 | - |
dc.citation.endPage | 1665 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSURGERY, Vol.137(6) : 1656-1665, 2022-12 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.