Cited 18 times in
Clinical Characteristics of Macrolide-Refractory Mycoplasma pneumoniae Pneumonia in Korean Children: A Multicenter Retrospective Study
DC Field | Value | Language |
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dc.contributor.author | 이용주 | - |
dc.date.accessioned | 2023-03-10T01:32:55Z | - |
dc.date.available | 2023-03-10T01:32:55Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193217 | - |
dc.description.abstract | Mycoplasma pneumoniae is a major causative pathogen of community-acquired pneumonia in children, and the treatment of choice is macrolides. There is an increasing trend in reports of refractory clinical responses despite macrolide treatment due to the emergence of macrolide-resistant M. pneumoniae. Early discrimination of macrolide-refractory M. pneumoniae pneumonia (MrMP) from macrolide-sensitive M. pneumoniae pneumonia (MSMP) is vital; however, testing for macrolide susceptibility at the time of admission is not feasible. This study aimed to identify the characteristics of MrMP in Korean children, in comparison with those of MSMP. In this multicenter study, board-certified pediatric pulmonologists at 22 tertiary hospitals reviewed the medical records from 2010 to 2015 of 5294 children who were hospitalized with M. pneumoniae pneumonia and administered macrolides as the initial treatment. One-way analysis of variance and the Kruskal-Wallis test were used to compare differences between groups. Of 5294 patients (mean age, 5.6 years) included in this analysis, 240 (4.5%), 925 (17.5%), and 4129 (78.0%) had MrMP, macrolide-less effective M. pneumoniae pneumonia, and MSMP, respectively. Compared with the MSMP group, the MrMP group had a longer fever duration, overall (13.0 days) and after macrolide use (8.0 days). A higher proportion of MrMP patients had respiratory distress, pleural effusion, and lobar pneumonia. The mean aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and C-reactive protein levels were the highest in the MrMP group, along with higher incidences of extrapulmonary manifestations and atelectasis (during and post infection). Pre-existing conditions were present in 17.4% (n = 725/4159) of patients, with asthma being the most common (n = 334/4811, 6.9%). This study verified that MrMP patients show more severe initial radiographic findings and clinical courses than MSMP patients. MrMP should be promptly managed by agents other than macrolides. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Clinical Characteristics of Macrolide-Refractory Mycoplasma pneumoniae Pneumonia in Korean Children: A Multicenter Retrospective Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Yun Jung Choi | - |
dc.contributor.googleauthor | Eun Hee Chung | - |
dc.contributor.googleauthor | Eun Lee | - |
dc.contributor.googleauthor | Chul-Hong Kim | - |
dc.contributor.googleauthor | Yong Ju Lee | - |
dc.contributor.googleauthor | Hyo-Bin Kim | - |
dc.contributor.googleauthor | Bong-Seong Kim | - |
dc.contributor.googleauthor | Hyung Young Kim | - |
dc.contributor.googleauthor | Yoojung Cho | - |
dc.contributor.googleauthor | Ju-Hee Seo | - |
dc.contributor.googleauthor | In Suk Sol | - |
dc.contributor.googleauthor | Myongsoon Sung | - |
dc.contributor.googleauthor | Dae Jin Song | - |
dc.contributor.googleauthor | Young Min Ahn | - |
dc.contributor.googleauthor | Hea Lin Oh | - |
dc.contributor.googleauthor | Jinho Yu | - |
dc.contributor.googleauthor | Sungsu Jung | - |
dc.contributor.googleauthor | Kyung Suk Lee | - |
dc.contributor.googleauthor | Ju Suk Lee | - |
dc.contributor.googleauthor | Gwang Cheon Jang | - |
dc.contributor.googleauthor | Yoon-Young Jang | - |
dc.contributor.googleauthor | Hai Lee Chung | - |
dc.contributor.googleauthor | Sung-Min Choi | - |
dc.contributor.googleauthor | Man Yong Han | - |
dc.contributor.googleauthor | Jung Yeon Shim | - |
dc.contributor.googleauthor | Jin Tack Kim | - |
dc.contributor.googleauthor | Chang-Keun Kim | - |
dc.contributor.googleauthor | Hyeon-Jong Yang | - |
dc.contributor.googleauthor | Dong In Suh | - |
dc.identifier.doi | 10.3390/jcm11020306 | - |
dc.contributor.localId | A02983 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 35054002 | - |
dc.subject.keyword | Mycoplasma pneumoniae pneumonia | - |
dc.subject.keyword | children | - |
dc.subject.keyword | macrolide refractory Mycoplasma pneumoniae pneumonia | - |
dc.contributor.alternativeName | Lee, Yong Ju | - |
dc.contributor.affiliatedAuthor | 이용주 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 306 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.11(2) : 306, 2022-01 | - |
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