Cited 6 times in
Adiponectin-derived pentapeptide ameliorates psoriasiform skin inflammation by suppressing IL-17 production in γδT cells
DC Field | Value | Language |
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dc.contributor.author | 김태균 | - |
dc.date.accessioned | 2023-03-10T01:31:37Z | - |
dc.date.available | 2023-03-10T01:31:37Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 0923-1811 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193204 | - |
dc.description.abstract | Background: Psoriasis is a common immunologic chronic skin disease that affects at least 100 million individuals worldwide. Adiponectin is associated with psoriasis and suppresses psoriasiform inflammation. Recently, a small-sized transdermally deliverable 5-mer peptide (GLYYF; P5) was discovered as a potential adiponectin receptor 1 agonist. Objectives: To confirm reduction in adiponectin protein level in the human skin and investigate whether functional adiponectin replenishment by topical P5 application improves psoriasiform skin inflammation. Methods: Adiponectin protein expression in the skin of individuals with psoriasis and normal skin was examined by immunofluorescence staining. Imiquimod-induced psoriasis-like skin inflammation was induced in wild-type (WT) and adiponectin-deficient (Adipoq-/-) mice. Vehicle and P5 were topically applied to the back skin and ears of mice. Histological study, reverse-transcription quantitative polymerase chain reaction, multiplex-bead array assay, and flow cytometric analysis were performed. Results: Adiponectin protein expression was downregulated both in the epidermis and dermis of psoriatic lesions as compared to that in the normal skin. Topically applied P5 attenuated the severity of imiquimod-induced psoriatic dermatitis in both WT and Adipoq-/- mice by decreasing the expression of psoriasis-related cytokines (Il17a, Il1b, Il6, and Tnfa). P5 application significantly reduced the proportion of interleukin-17A-producing γδT cells. Conclusion: Transdermally deliverable adiponectin receptor 1 agonist, P5, can be a potential peptide drug to manage psoriasis by mediating the anti-psoriatic effect of adiponectin. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF DERMATOLOGICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adiponectin / metabolism | - |
dc.subject.MESH | Adiponectin / pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Eczema* | - |
dc.subject.MESH | Imiquimod | - |
dc.subject.MESH | Inflammation / metabolism | - |
dc.subject.MESH | Interleukin-17 / metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Psoriasis* / chemically induced | - |
dc.subject.MESH | Psoriasis* / drug therapy | - |
dc.subject.MESH | Receptors, Adiponectin / metabolism | - |
dc.subject.MESH | Skin / pathology | - |
dc.title | Adiponectin-derived pentapeptide ameliorates psoriasiform skin inflammation by suppressing IL-17 production in γδT cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Joong Heon Suh | - |
dc.contributor.googleauthor | Yuri Lee | - |
dc.contributor.googleauthor | Jungyoon Ohn | - |
dc.contributor.googleauthor | Eun Ju Kim | - |
dc.contributor.googleauthor | Tae-Gyun Kim | - |
dc.contributor.googleauthor | Seong Jin Jo | - |
dc.contributor.googleauthor | Sung Joon Kim | - |
dc.contributor.googleauthor | Jin Ho Chung | - |
dc.identifier.doi | 10.1016/j.jdermsci.2022.03.003 | - |
dc.contributor.localId | A05324 | - |
dc.relation.journalcode | J01370 | - |
dc.identifier.eissn | 1873-569X | - |
dc.identifier.pmid | 35331618 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0923181122000639 | - |
dc.subject.keyword | Adiponectin | - |
dc.subject.keyword | Adiponectin receptor 1 | - |
dc.subject.keyword | Adiponectin receptor 1 agonist | - |
dc.subject.keyword | Peptide | - |
dc.subject.keyword | Psoriasiform dermatitis | - |
dc.subject.keyword | Psoriasis | - |
dc.contributor.alternativeName | Kim, Tae-Gyun | - |
dc.contributor.affiliatedAuthor | 김태균 | - |
dc.citation.volume | 106 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 45 | - |
dc.citation.endPage | 52 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DERMATOLOGICAL SCIENCE, Vol.106(1) : 45-52, 2022-04 | - |
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