Cited 4 times in
Factors Affecting the Circulating Levels of Oxyntomodulin in Health and After Acute Pancreatitis
DC Field | Value | Language |
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dc.contributor.author | 조재림 | - |
dc.date.accessioned | 2023-03-10T01:30:13Z | - |
dc.date.available | 2023-03-10T01:30:13Z | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 0885-3177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193195 | - |
dc.description.abstract | Objectives: To investigate the factors associated with the circulating levels of oxyntomodulin in healthy individuals and individuals after an episode of acute pancreatitis (AP). Methods: Blood samples were collected from all participants after an overnight fast and analyzed for 28 biomarkers. Participants also underwent comprehensive body composition analysis on a 3-T magnetic resonance imaging scanner. Regression analyses were done to investigate the associations between oxyntomodulin and the studied factors. Results: The study included 105 individuals who had a primary diagnosis of AP and 58 healthy individuals. Peptide YY (B coefficient, 0.094; 95% confidence interval [95% CI], 0.164-0.123), pancreatic polypeptide (0.048; 95% CI, 0.030-0.066), and leptin (0.394; 95% CI, 0.128-0.661) had significant associations with oxyntomodulin in healthy individuals. Peptide YY was the most prominent factor associated with oxyntomodulin, explaining 60% of its variance in health. Cholecystokinin (0.014; 95% CI, 0.010-0.018), amylin (-0.107; 95% CI, -0.192 to -0.021), and glycated hemoglobin (-0.761; 95% CI, -1.249 to -0.273) had significant associations with oxyntomodulin in individuals after AP. Cholecystokinin was the most prominent factor associated with oxyntomodulin, explaining 44% of its variance after AP. Conclusions: Factors affecting the circulating levels of oxyntomodulin are different in health and after AP. These insights will enable the determination of populations that benefit from oxyntomodulin therapeutics in the future. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | PANCREAS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Cholecystokinin | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Oxyntomodulin* | - |
dc.subject.MESH | Pancreatitis* / diagnosis | - |
dc.subject.MESH | Peptide YY | - |
dc.title | Factors Affecting the Circulating Levels of Oxyntomodulin in Health and After Acute Pancreatitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학교실) | - |
dc.contributor.googleauthor | Sakina H Bharmal | - |
dc.contributor.googleauthor | Juyeon Ko | - |
dc.contributor.googleauthor | Wandia Kimita | - |
dc.contributor.googleauthor | Jaelim Cho | - |
dc.contributor.googleauthor | Maxim S Petrov | - |
dc.identifier.doi | 10.1097/MPA.0000000000002114 | - |
dc.contributor.localId | A03895 | - |
dc.relation.journalcode | J02463 | - |
dc.identifier.eissn | 1536-4828 | - |
dc.identifier.pmid | 36395403 | - |
dc.identifier.url | https://journals.lww.com/pancreasjournal/Fulltext/2022/08000/Factors_Affecting_the_Circulating_Levels_of.11.aspx | - |
dc.contributor.alternativeName | Cho, Jae Lim | - |
dc.contributor.affiliatedAuthor | 조재림 | - |
dc.citation.volume | 51 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 774 | - |
dc.citation.endPage | 783 | - |
dc.identifier.bibliographicCitation | PANCREAS, Vol.51(7) : 774-783, 2022-08 | - |
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