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Differences in intrinsic functional networks in patients with essential tremor who had good and poor long-term responses after thalamotomy performed using MR-guided ultrasound

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dc.contributor.author장원석-
dc.contributor.author장진우-
dc.contributor.author정현호-
dc.contributor.author장경원-
dc.contributor.author박해정-
dc.date.accessioned2023-03-10T01:23:33Z-
dc.date.available2023-03-10T01:23:33Z-
dc.date.issued2022-07-
dc.identifier.issn0022-3085-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/193144-
dc.description.abstractObjective: Thalamotomy at the nucleus ventralis intermedius using MR-guided focused ultrasound has been an effective treatment method for essential tremor (ET). However, this is not true for all cases, even for successful ablation. How the brain differs in patients with ET between those with long-term good and poor outcomes is not clear. To analyze the functional connectivity difference between patients in whom thalamotomy was effective and those in whom thalamotomy was ineffective and its prognostic role in ET treatment, the authors evaluated preoperative resting-state functional MRI in thalamotomy-treated patients. Methods: Preoperative resting-state functional MRI data in 85 patients with ET, who were experiencing tremor relief at the time of treatment and were followed up for a minimum of 6 months after the procedure, were collected for the study. The authors conducted a graph independent component analysis of the functional connectivity matrices of tremor-related networks. The patients were divided into thalamotomy-effective and thalamotomy-ineffective groups (thalamotomy-effective group, ≥ 50% motor symptom reduction; thalamotomy-ineffective group, < 50% motor symptom reduction at 6 months after treatment) and the authors compared network components between groups. Results: Seventy-two (84.7%) of the 85 patients showed ≥ 50% tremor reduction from baseline at 6 months after thalamotomy. The network analysis shows significant suppression of functional network components with connections between the areas of the cerebellum and the basal ganglia and thalamus, but enhancement of those between the premotor cortex and supplementary motor area in the noneffective group compared to the effective group. Conclusions: The present study demonstrates that patients in the noneffective group have suppressed functional subnetworks in the cerebellum and subcortex regions and have enhanced functional subnetworks among motor-sensory cortical networks compared to the thalamotomy-effective group. Therefore, the authors suggest that the functional connectivity pattern might be a possible predictive factor for outcomes of MR-guided focused ultrasound thalamotomy.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Association of Neurological Surgeons-
dc.relation.isPartOfJOURNAL OF NEUROSURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHEssential Tremor* / diagnostic imaging-
dc.subject.MESHEssential Tremor* / surgery-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging / methods-
dc.subject.MESHThalamus / diagnostic imaging-
dc.subject.MESHThalamus / surgery-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTremor-
dc.subject.MESHVentral Thalamic Nuclei-
dc.titleDifferences in intrinsic functional networks in patients with essential tremor who had good and poor long-term responses after thalamotomy performed using MR-guided ultrasound-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorChongwon Pae-
dc.contributor.googleauthorMyung Ji Kim-
dc.contributor.googleauthorWon Seok Chang-
dc.contributor.googleauthorHyun Ho Jung-
dc.contributor.googleauthorKyung Won Chang-
dc.contributor.googleauthorJinseok Eo-
dc.contributor.googleauthorHae-Jeong Park-
dc.contributor.googleauthorJin Woo Chang-
dc.identifier.doi10.3171/2022.5.JNS22324-
dc.contributor.localIdA03454-
dc.contributor.localIdA03484-
dc.contributor.localIdA03775-
dc.relation.journalcodeJ01636-
dc.identifier.eissn1933-0693-
dc.identifier.pmid35901685-
dc.identifier.urlhttps://thejns.org/view/journals/j-neurosurg/138/2/article-p318.xml-
dc.subject.keywordbrain network-
dc.subject.keywordessential tremor-
dc.subject.keywordfunctional neurosurgery-
dc.subject.keywordgraph independent component analysis-
dc.subject.keywordprognosis-
dc.subject.keywordthalamotomy-
dc.contributor.alternativeNameChang, Won Seok-
dc.contributor.affiliatedAuthor장원석-
dc.contributor.affiliatedAuthor장진우-
dc.contributor.affiliatedAuthor정현호-
dc.citation.volume138-
dc.citation.number2-
dc.citation.startPage318-
dc.citation.endPage328-
dc.identifier.bibliographicCitationJOURNAL OF NEUROSURGERY, Vol.138(2) : 318-328, 2022-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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