Cited 1 times in
Time-dependent pathobiological and physiological changes of implanted vein grafts in a canine model
DC Field | Value | Language |
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dc.contributor.author | 김정환 | - |
dc.contributor.author | 김효현 | - |
dc.contributor.author | 윤영남 | - |
dc.date.accessioned | 2023-03-10T01:22:29Z | - |
dc.date.available | 2023-03-10T01:22:29Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 1937-5387 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193138 | - |
dc.description.abstract | Although autologous vein grafting is essential, the high vein failure rate and specific clinical interventions are not clear, so a potential treatment is critically needed; thus, complex analyses of the relationship between pathobiological and physiological processes in preclinical are essential. The interposition of the femoral vein was performed in a canine model. Maximized expansion and velocity were measured at 8 weeks post-implantation, and a relative decrease was observed at 12 weeks. However, NI formation and NI/Media ratio significantly increased time dependently, and differences between the mechanical properties were observed. Additionally, RhoA-mediated TNF-α induced by rapid structural changes and high shear stress was confirmed. After adaptation to the arterial environment, vascular remodeling occurred by SMC proliferation and differentiation, apoptosis and autophagy were induced through YAP activity without vasodilation and RhoA activity. Our results show that understanding pathobiological processes in which time-dependent physiological changes contribute to vein failure can lead to a potential strategy. The implanted vein graft within the arterial environment undergoes pathobiological processes through RhoA and YAP activity, leading to pathophysiological changes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Stress, Mechanical | - |
dc.subject.MESH | Veins* / transplantation | - |
dc.title | Time-dependent pathobiological and physiological changes of implanted vein grafts in a canine model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.googleauthor | Eui Hwa Jang | - |
dc.contributor.googleauthor | Jung-Hwan Kim | - |
dc.contributor.googleauthor | Ji-Yeon Ryu | - |
dc.contributor.googleauthor | Jiyong Lee | - |
dc.contributor.googleauthor | Hyo-Hyun Kim | - |
dc.contributor.googleauthor | Young-Nam Youn | - |
dc.identifier.doi | 10.1007/s12265-022-10226-z | - |
dc.contributor.localId | A00905 | - |
dc.contributor.localId | A04741 | - |
dc.contributor.localId | A02576 | - |
dc.relation.journalcode | J04383 | - |
dc.identifier.eissn | 1937-5395 | - |
dc.identifier.pmid | 35244875 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s12265-022-10226-z | - |
dc.subject.keyword | Bypass graft | - |
dc.subject.keyword | Experimental animal models ,·Hemodynamic stress | - |
dc.subject.keyword | Vascular injury | - |
dc.subject.keyword | Vein failure | - |
dc.contributor.alternativeName | Kim, Jung Hwan | - |
dc.contributor.affiliatedAuthor | 김정환 | - |
dc.contributor.affiliatedAuthor | 김효현 | - |
dc.contributor.affiliatedAuthor | 윤영남 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1108 | - |
dc.citation.endPage | 1118 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol.15(5) : 1108-1118, 2022-10 | - |
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