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Real-World Effectiveness, Tolerability, and Safety of Dolutegravir/Lamivudine in Korea

DC Field Value Language
dc.contributor.author구남수-
dc.contributor.author김정호-
dc.contributor.author김진남-
dc.contributor.author송영구-
dc.contributor.author안진영-
dc.contributor.author염준섭-
dc.contributor.author이기현-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.date.accessioned2023-03-03T03:09:04Z-
dc.date.available2023-03-03T03:09:04Z-
dc.date.issued2022-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/192992-
dc.description.abstractMost studies on the real-world effectiveness and safety of dolutegravir/lamivudine (DTG/3TC) have been conducted in Western countries, and Asian reports are lacking. We evaluated the effectiveness and safety of DTG/3TC in Korean adult people living with HIV (PLWH). This retrospective study was conducted from July 2020 to July 2022 at a tertiary hospital in Korea. Those who were followed up for more than 12 months were included. We analyzed the baseline characteristics, effectiveness, resistant profiles, body weights, metabolic parameters, and safety of DTG/3TC treatment in 151 PLWH, dividing them into the treatment-naïve group and the switching group. The median DTG/3TC treatment durations in the treatment-naïve and switching groups were 507.5 and 525.0 days. In the treatment-naïve group, the viral RNA titer was undetectable at 6 and 12 months in 95% of patients. In the switching group, virologic suppression was well-maintained. Meanwhile, the creatinine levels were slightly elevated in both groups compared to baseline. Five participants complained of mild side effects, such as indigestion, constipation, diarrhea, and fatigue. However, no patient stopped treatment during the follow-up period. Since there was no virological failure or serious complications observed in this study, DTG/3TC may be a good treatment option for PLWH in Korea.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfVIRUSES-BASEL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAnti-HIV Agents* / adverse effects-
dc.subject.MESHHIV Infections* / drug therapy-
dc.subject.MESHHIV-1*-
dc.subject.MESHHumans-
dc.subject.MESHLamivudine / adverse effects-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.titleReal-World Effectiveness, Tolerability, and Safety of Dolutegravir/Lamivudine in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorKi Hyun Lee-
dc.contributor.googleauthorJinnam Kim-
dc.contributor.googleauthorJung Ah Lee-
dc.contributor.googleauthorChang Hyup Kim-
dc.contributor.googleauthorJin Young Ahn-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorJoon-Sup Yeom-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorJung Ho Kim-
dc.identifier.doi10.3390/v14112558-
dc.contributor.localIdA00189-
dc.contributor.localIdA00902-
dc.contributor.localIdA05112-
dc.contributor.localIdA02037-
dc.contributor.localIdA02267-
dc.contributor.localIdA02353-
dc.contributor.localIdA06174-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ03792-
dc.identifier.eissn1999-4915-
dc.identifier.pmid36423167-
dc.subject.keywordAsia-
dc.subject.keywordHIV infection-
dc.subject.keyworddolutegravir/lamivudine-
dc.subject.keywordeffectiveness-
dc.subject.keywordsafety-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.affiliatedAuthor구남수-
dc.contributor.affiliatedAuthor김정호-
dc.contributor.affiliatedAuthor김진남-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor안진영-
dc.contributor.affiliatedAuthor염준섭-
dc.contributor.affiliatedAuthor이기현-
dc.contributor.affiliatedAuthor정수진-
dc.contributor.affiliatedAuthor최준용-
dc.citation.volume14-
dc.citation.number11-
dc.citation.startPage2558-
dc.identifier.bibliographicCitationVIRUSES-BASEL, Vol.14(11) : 2558, 2022-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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