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Identification of Single Nucleotide Polymorphisms as Biomarkers for Recurrent Pregnancy Loss in Korean Women

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dc.contributor.author김혜인-
dc.contributor.author서석교-
dc.contributor.author윤보현-
dc.contributor.author이병석-
dc.contributor.author이재훈-
dc.contributor.author조시현-
dc.contributor.author최영식-
dc.date.accessioned2023-03-03T03:05:33Z-
dc.date.available2023-03-03T03:05:33Z-
dc.date.issued2022-11-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/192986-
dc.description.abstractBackground: Single nucleotide polymorphisms (SNPs) are reportedly associated with repeated abortion. Thus, genetic analysis based on race is the key to developing accurate diagnostic tests. This study analyzed the genetic polymorphisms of recurrent pregnancy loss (RPL) patients among Korean women compared to the controls. Methods: In 53 women of RPL group and 50 controls, the genetic analysis was performed. The genotype distribution and allele frequency were analyzed statistically for the difference between the two groups. The association between each SNP marker and RPL risk was analyzed. Results: The genotypes of LEPR, endothelial nitric oxide synthase (eNOS), KDR, miR-27a, miR-449b, and tumor necrosis factor-alpha (TNF-α) were analyzed using odds ratio (OR) with 95% confidence intervals (CIs). Only the AG genotype of miR-449b (A>G) polymorphism showed significant association with the risk of RPL when compared to the AA genotype (OR, 2.39). The combination of GG/AG+GG/CA+AA genotypes for eNOS/miR-449b/TNF-α was associated with 7.36-fold higher risk of RPL (OR, 7.36). The GG/AG+GG combination for eNOS/miR-449b showed 2.43-fold higher risk for RPL (OR, 2.43). The combination of AG+GG/CA+AA genotypes for miR-449b/TNF-α showed a significant association with the risk of RPL (OR, 7.60). From the haplotype-based analysis, the G-G-A haplotype of eNOS/miR-449b/TNF-α and the G-A haplotype of miR-449b/TNF-α were associated with increased risk of RPL (OR, 19.31; OR, 22.08, respectively). Conclusion: There is a significant association between the risk of RPL and miR-449b/TNF-α combination, and therefore, genetic analysis for specific combined genotypes can be an important screening method for RPL in Korean women.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAbortion, Habitual* / diagnosis-
dc.subject.MESHAbortion, Habitual* / genetics-
dc.subject.MESHBiomarkers-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHMicroRNAs* / genetics-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHPregnancy-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTumor Necrosis Factor-alpha / genetics-
dc.titleIdentification of Single Nucleotide Polymorphisms as Biomarkers for Recurrent Pregnancy Loss in Korean Women-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorHye In Kim-
dc.contributor.googleauthorEun A Choi-
dc.contributor.googleauthorEun Chan Paik-
dc.contributor.googleauthorSoohyeon Park-
dc.contributor.googleauthorYu Im Hwang-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorSeok Kyo Seo-
dc.contributor.googleauthorSiHyun Cho-
dc.contributor.googleauthorYoung Sik Choi-
dc.contributor.googleauthorByung Seok Lee-
dc.contributor.googleauthorJimyeong Park-
dc.contributor.googleauthorSanghoo Lee-
dc.contributor.googleauthorKyoung-Ryul Lee-
dc.contributor.googleauthorBo Hyon Yun-
dc.identifier.doi10.3346/jkms.2022.37.e336-
dc.contributor.localIdA05969-
dc.contributor.localIdA01888-
dc.contributor.localIdA02555-
dc.contributor.localIdA02795-
dc.contributor.localIdA04636-
dc.contributor.localIdA03846-
dc.contributor.localIdA04114-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid36631028-
dc.subject.keywordMicroRNAs-
dc.subject.keywordMiscarriage-
dc.subject.keywordPlasma-
dc.subject.keywordPregnancy-
dc.subject.keywordRecurrent Pregnancy Loss-
dc.contributor.alternativeNameKim, Hye In-
dc.contributor.affiliatedAuthor김혜인-
dc.contributor.affiliatedAuthor서석교-
dc.contributor.affiliatedAuthor윤보현-
dc.contributor.affiliatedAuthor이병석-
dc.contributor.affiliatedAuthor이재훈-
dc.contributor.affiliatedAuthor조시현-
dc.contributor.affiliatedAuthor최영식-
dc.citation.volume37-
dc.citation.number46-
dc.citation.startPagee336-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.37(46) : e336, 2022-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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