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Risk factors and outcomes with surgical bioprosthetic mitral valve dysfunction

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dc.contributor.author고규용-
dc.contributor.author곽서연-
dc.contributor.author심지영-
dc.contributor.author조익성-
dc.contributor.author하종원-
dc.contributor.author홍그루-
dc.contributor.author곽서연-
dc.date.accessioned2023-03-03T03:03:35Z-
dc.date.available2023-03-03T03:03:35Z-
dc.date.issued2023-01-
dc.identifier.issn1355-6037-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/192975-
dc.description.abstractBackground: There are insufficient data regarding the risk factors associated with valve dysfunction of bioprosthetic valves in the mitral position This study aimed to investigate the factors associated with bioprosthetic mitral valve (MV) dysfunction (MVD). Methods: A total of 245 patients (age 67.2±11.2 years, 74.9% women) who were followed up for more than 5 years after surgical bioprosthetic MV replacement were analysed in the setting of retrospective study design. MVD was defined as an increased mean gradient of >5 mm Hg with limited leaflet motion and/or newly developed MV regurgitation of at least moderate severity on follow-up echocardiography. The clinical outcome was defined as a composite of cardiovascular mortality, redo MV surgery or intervention and heart failure-related hospitalisations. Results: During a median of 96.0 months (IQR 67.0-125.0 months), bioprosthetic MVD occurred in 66 (27.6%) patients. Factors associated with bioprosthetic MVD detected by multivariate regression analysis were age at surgery (HR 0.98, 95% CI 0.96 to 0.99, p<0.001), chronic kidney disease (HR 3.27, 95% CI 1.74 to 6.12, p<0.001), elevated mean diastolic pressure gradient >5.5 mm Hg across the bioprosthetic MV early after operation (HR 2.02, 95% CI 1.08 to 3.78, p=0.028) and average haemoglobin level after surgery (HR 0.80, 95% CI 0.67 to 0.96, p=0.015). Patients with bioprosthetic MVD showed significantly poorer clinical outcomes than those without bioprosthetic MVD (log-rank p<0.001). Conclusions: Young age at operation, chronic kidney disease, elevated pressure gradient across the bioprosthetic MV early after surgery and postsurgical anaemia are associated with bioprosthetic MVD. Bioprosthetic MVD is associated with poor clinical outcomes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBMJ Pub. Group.-
dc.relation.isPartOfHEART-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHBioprosthesis* / adverse effects-
dc.subject.MESHFemale-
dc.subject.MESHHeart Valve Diseases*-
dc.subject.MESHHeart Valve Prosthesis Implantation* / adverse effects-
dc.subject.MESHHeart Valve Prosthesis* / adverse effects-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMitral Valve / diagnostic imaging-
dc.subject.MESHMitral Valve / surgery-
dc.subject.MESHProsthesis Failure-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTreatment Outcome-
dc.titleRisk factors and outcomes with surgical bioprosthetic mitral valve dysfunction-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSeo-Yeon Gwak-
dc.contributor.googleauthorKyu-Yong Ko-
dc.contributor.googleauthorIksung Cho-
dc.contributor.googleauthorGeu-Ru Hong-
dc.contributor.googleauthorJong-Won Ha-
dc.contributor.googleauthorChi Young Shim-
dc.identifier.doi10.1136/heartjnl-2022-321307-
dc.contributor.localIdA06274-
dc.contributor.localIdA06352-
dc.contributor.localIdA02213-
dc.contributor.localIdA03888-
dc.contributor.localIdA04257-
dc.contributor.localIdA04386-
dc.relation.journalcodeJ00976-
dc.identifier.eissn1468-201X-
dc.identifier.pmid36371666-
dc.identifier.urlhttps://heart.bmj.com/content/109/1/63.long-
dc.subject.keywordEchocardiography-
dc.subject.keywordHeart Valve Prosthesis-
dc.subject.keywordMitral Valve Insufficiency-
dc.subject.keywordMitral Valve Stenosis-
dc.subject.keywordRisk Factors-
dc.contributor.alternativeNameGo, Kyu-Yong-
dc.contributor.affiliatedAuthor고규용-
dc.contributor.affiliatedAuthor심지영-
dc.contributor.affiliatedAuthor조익성-
dc.contributor.affiliatedAuthor하종원-
dc.contributor.affiliatedAuthor홍그루-
dc.citation.volume109-
dc.citation.number1-
dc.citation.startPage63-
dc.citation.endPage69-
dc.identifier.bibliographicCitationHEART, Vol.109(1) : 63-69, 2023-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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