Cited 3 times in
PSMA Immunohistochemistry in Hepatic Neoplasms: A Promising Diagnostic Marker With Potential Theranostic Applications
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.date.accessioned | 2023-03-03T02:29:00Z | - |
dc.date.available | 2023-03-03T02:29:00Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 0147-5185 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192832 | - |
dc.description.abstract | Accurate classification of well-differentiated hepatocellular neoplasms can be challenging especially in core biopsies. Prostate-specific membrane antigen (PSMA) has been shown to highlight tumor-associated neovasculature in many nonprostatic solid tumors including hepatocellular carcinoma (HCC). Archived 164 hepatectomies and explants with 68 HCCs, 31 hepatocellular adenoma (HA), 24 dysplastic nodules (DN), and 42 metastases were retrieved, and pathologic parameters were evaluated. Sensitivity, specificity, accuracy, positive, and negative predictive values for correct diagnosis of HCC were calculated for PSMA and CD34 immunostains in tissue sections and HCC tissue microarrays. PSMA positivity was defined as capillarized sinusoidal/tumor-associated vessel staining involving ≥5% of the tumor area. In all, 55/68 (80.9%) HCC and 37/42 (88.1%) of liver metastasis were PSMA positive. PSMA was negative in HA, DN, and background liver (100% specificity). CD34 had a 98.5% sensitivity but a 65.5% specificity in identifying HCC. PSMA sensitivity remained high in the HCC tissue microarray (89.7%). PSMA was more accurate than CD34 (95.5% vs. 69.7%) in distinguishing grade 1 HCC from HA and high-grade DN while retaining high sensitivity (80%). The degree of PSMA positivity in HCC was greater in older, male, and human immunodeficiency virus patients ( P <0.05). No associations were found between PSMA staining and other tumor parameters ( P >0.05). PSMA is a marker of neoangiogenesis with increased expression in both primary and metastatic hepatic malignancies. Neovascular PSMA expression is more specific and accurate than CD34 for differentiating HCC from benign and precursor hepatic lesions. Diagnostic and therapeutic utility of PSMA radioligands in malignant liver neoplasms warrant further clinical investigations. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wolters Kluwer Health, Inc. | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF SURGICAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adenoma, Liver Cell* / diagnosis | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antigens, CD34 / metabolism | - |
dc.subject.MESH | Biomarkers, Tumor / metabolism | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / diagnosis | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / therapy | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperplasia | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Liver Neoplasms* / diagnosis | - |
dc.subject.MESH | Liver Neoplasms* / metabolism | - |
dc.subject.MESH | Liver Neoplasms* / therapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Precision Medicine | - |
dc.title | PSMA Immunohistochemistry in Hepatic Neoplasms: A Promising Diagnostic Marker With Potential Theranostic Applications | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Michel Kmeid | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Taek Chung | - |
dc.contributor.googleauthor | Georgi Lukose | - |
dc.contributor.googleauthor | Luz Sullivan | - |
dc.contributor.googleauthor | Rupinder Brar | - |
dc.contributor.googleauthor | Hwajeong Lee | - |
dc.identifier.doi | 10.1097/PAS.0000000000001971 | - |
dc.contributor.localId | A01563 | - |
dc.relation.journalcode | J00120 | - |
dc.identifier.eissn | 1532-0979 | - |
dc.identifier.pmid | 36190927 | - |
dc.identifier.url | https://journals.lww.com/ajsp/Fulltext/2022/12000/PSMA_Immunohistochemistry_in_Hepatic_Neoplasms__A.10.aspx | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | 박영년 | - |
dc.citation.volume | 46 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1688 | - |
dc.citation.endPage | 1699 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF SURGICAL PATHOLOGY, Vol.46(12) : 1688-1699, 2022-12 | - |
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