Cited 2 times in
Tranexamic Acid and Intraoperative and Postoperative Accumulative Bleeding in Elective Degenerative Spine Surgery
DC Field | Value | Language |
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dc.contributor.author | 권지원 | - |
dc.contributor.author | 김혜진 | - |
dc.contributor.author | 문성환 | - |
dc.contributor.author | 이병호 | - |
dc.contributor.author | 이보라 | - |
dc.contributor.author | 최용선 | - |
dc.date.accessioned | 2023-03-03T02:21:09Z | - |
dc.date.available | 2023-03-03T02:21:09Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192809 | - |
dc.description.abstract | Purpose: Spinal surgeries are often associated with a high incidence of perioperative blood loss, which poses several complications. Much current research focuses on the importance of antifibrinolytic drugs during spinal surgeries to reduce blood loss, which can also reduce the risk of the need for blood transfusions. We evaluated the effects of prophylactic, low-dose tranexamic acid (TXA) in spinal fusion surgeries on blood loss, blood transfusions, and associated complications. Materials and methods: TXA was administered to 90 patients at a constant infusion rate of 10 mg/kg for 20 minutes after anesthesia induction, followed by a maintenance dose of 1 mg/kg/h until the end of the operation. An additional 91 patients were included as controls. Results: There were no significant differences between the study groups in terms of intraoperative blood loss, which was 500 mL for both groups (p>0.999). Also, intraoperative blood transfusion requirements were similar between both groups (p=0.330). Mean blood transfusion amounts were 125±35 mL for patients in the TXA group and 85±25 mL in the control group. However, there was a significant reduction in postoperative blood transfusion (p=0.003) in the TXA group. Only three cases in the TXA group required blood transfusion, while 15 cases in the control group did. Conclusion: We confirmed that low dose TXA has no effect on intraoperative blood loss volume or blood transfusion requirements and that it can significantly reduce the need for postoperative blood transfusions. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antifibrinolytic Agents* / therapeutic use | - |
dc.subject.MESH | Blood Loss, Surgical / prevention & control | - |
dc.subject.MESH | Blood Transfusion | - |
dc.subject.MESH | Elective Surgical Procedures | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Tranexamic Acid* / therapeutic use | - |
dc.title | Tranexamic Acid and Intraoperative and Postoperative Accumulative Bleeding in Elective Degenerative Spine Surgery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학교실) | - |
dc.contributor.googleauthor | Mahmoud Abdou | - |
dc.contributor.googleauthor | Ji-Won Kwon | - |
dc.contributor.googleauthor | Hye Jin Kim | - |
dc.contributor.googleauthor | Bora Lee | - |
dc.contributor.googleauthor | Yong Seon Choi | - |
dc.contributor.googleauthor | Seong-Hwan Moon | - |
dc.contributor.googleauthor | Byung Ho Lee | - |
dc.identifier.doi | 10.3349/ymj.2022.0163 | - |
dc.contributor.localId | A06027 | - |
dc.contributor.localId | A05706 | - |
dc.contributor.localId | A01365 | - |
dc.contributor.localId | A02801 | - |
dc.contributor.localId | A02803 | - |
dc.contributor.localId | A04119 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 36168245 | - |
dc.subject.keyword | Blood loss | - |
dc.subject.keyword | PLIF | - |
dc.subject.keyword | blood transfusion | - |
dc.subject.keyword | intraoperative | - |
dc.subject.keyword | postoperative | - |
dc.subject.keyword | tranexamic acid | - |
dc.contributor.alternativeName | Kwon, Ji-Won | - |
dc.contributor.affiliatedAuthor | 권지원 | - |
dc.contributor.affiliatedAuthor | 김혜진 | - |
dc.contributor.affiliatedAuthor | 문성환 | - |
dc.contributor.affiliatedAuthor | 이병호 | - |
dc.contributor.affiliatedAuthor | 이보라 | - |
dc.contributor.affiliatedAuthor | 최용선 | - |
dc.citation.volume | 63 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 927 | - |
dc.citation.endPage | 932 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.63(10) : 927-932, 2022-10 | - |
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