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Nationwide Surveillance of Antifungal Resistance of Candida Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS
DC Field | Value | Language |
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dc.contributor.author | 김도균 | - |
dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2023-03-03T02:12:39Z | - |
dc.date.available | 2023-03-03T02:12:39Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192772 | - |
dc.description.abstract | We incorporated nationwide Candida antifungal surveillance into the Korea Global Antimicrobial Resistance Surveillance System (Kor-GLASS) for bacterial pathogens. We prospectively collected and analyzed complete non-duplicate blood isolates and information from nine sentinel hospitals during 2020-2021, based on GLASS early implementation protocol for the inclusion of Candida species. Candida species ranked fourth among 10,758 target blood pathogens and second among 4050 hospital-origin blood pathogens. Among 766 Candida blood isolates, 87.6% were of hospital origin, and 41.3% occurred in intensive care unit patients. Adults > 60 years of age accounted for 75.7% of cases. Based on species-specific clinical breakpoints, non-susceptibility to fluconazole, voriconazole, caspofungin, micafungin, and anidulafungin was found in 21.1% (154/729), 4.0% (24/596), 0.1% (1/741), 0.0% (0/741), and 0.1% (1/741) of the isolates, respectively. Fluconazole resistance was determined in 0% (0/348), 2.2% (3/135, 1 Erg11 mutant), 5.3% (7/133, 6 Pdr1 mutants), and 5.6% (6/108, 4 Erg11 and 1 Cdr1 mutants) of C. albicans, C. tropicalis, C. glabrata, and C. parapsilosis isolates, respectively. An echinocandin-resistant C. glabrata isolate harbored an F659Y mutation in Fks2p. The inclusion of Candida species in the Kor-GLASS system generated well-curated surveillance data and may encourage global Candida surveillance efforts using a harmonized GLASS system. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | JOURNAL OF FUNGI | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Nationwide Surveillance of Antifungal Resistance of Candida Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Eun Jeong Won | - |
dc.contributor.googleauthor | Min Ji Choi | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Dokyun Kim | - |
dc.contributor.googleauthor | Kyeong Seob Shin | - |
dc.contributor.googleauthor | Jeong Hwan Shin | - |
dc.contributor.googleauthor | Young Ree Kim | - |
dc.contributor.googleauthor | Hyun Soo Kim | - |
dc.contributor.googleauthor | Young Ah Kim | - |
dc.contributor.googleauthor | Young Uh | - |
dc.contributor.googleauthor | Namhee Ryoo | - |
dc.contributor.googleauthor | Jeong Su Park | - |
dc.contributor.googleauthor | Kyoung Un Park | - |
dc.contributor.googleauthor | Seung A Byun | - |
dc.contributor.googleauthor | Ga Yeong Lee | - |
dc.contributor.googleauthor | Soo Hyun Kim | - |
dc.contributor.googleauthor | Jong Hee Shin | - |
dc.identifier.doi | 10.3390/jof8100996 | - |
dc.contributor.localId | A04891 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J04005 | - |
dc.identifier.eissn | 2309-608X | - |
dc.identifier.pmid | 36294562 | - |
dc.subject.keyword | Candida species | - |
dc.subject.keyword | GLASS | - |
dc.subject.keyword | antifungal surveillance | - |
dc.subject.keyword | candidemia | - |
dc.contributor.alternativeName | Kim, Dokyun | - |
dc.contributor.affiliatedAuthor | 김도균 | - |
dc.contributor.affiliatedAuthor | 정석훈 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 996 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNGI, Vol.8(10) : 996, 2022-09 | - |
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