Cited 14 times in
Trajectory of Antidepressant Effects after Single- or Two-Dose Administration of Psilocybin: A Systematic Review and Multivariate Meta-Analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2023-03-03T02:11:56Z | - |
dc.date.available | 2023-03-03T02:11:56Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192763 | - |
dc.description.abstract | We examined the cardiovascular safety, acceptability, and trajectory of the antidepressant effects of psilocybin after single- or two-dose administration. Four major electronic databases were systematically searched. Data were pooled using a multivariate random-effects meta-analysis. Primary outcomes were changes in depressive symptoms. Secondary outcomes were cardiovascular safety and acceptability. Ten studies were included. The estimated effect sizes (standardized mean difference (SMD) with 95% confidence intervals) for psilocybin were -0.75 (-1.15 to -0.35) on day 1, -1.74 (-2.15 to -1.32) at 1 week, -1.35 (-1.77 to -0.93) at 1 month, -0.91 (-1.31 to -0.51) at 3 months, and -1.12 (-1.56 to -0.68) at 6 months. Higher doses and two sessions of psilocybin treatment were significantly associated with superior antidepressant effects. The all-cause discontinuation and heart rate after psilocybin administration were comparable to placebo; meanwhile, psilocybin increased systolic and diastolic blood pressure by 19.00 mmHg and 8.66 mmHg, respectively. There were no significant differences between SMD derived from placebo-controlled trials compared to those from pre-post changes and SMD in randomized controlled trials (RCTs) compared to those in non-RCTs. The present study demonstrates that single- or two-dose psilocybin administration has rapid and sustained antidepressant effects for up to 6 months, with favorable cardiovascular safety and acceptability. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Trajectory of Antidepressant Effects after Single- or Two-Dose Administration of Psilocybin: A Systematic Review and Multivariate Meta-Analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Chia-Ling Yu | - |
dc.contributor.googleauthor | Chih-Sung Liang | - |
dc.contributor.googleauthor | Fu-Chi Yang | - |
dc.contributor.googleauthor | Yu-Kang Tu | - |
dc.contributor.googleauthor | Chih-Wei Hsu | - |
dc.contributor.googleauthor | Andre F Carvalho | - |
dc.contributor.googleauthor | Brendon Stubbs | - |
dc.contributor.googleauthor | Trevor Thompson | - |
dc.contributor.googleauthor | Chia-Kuang Tsai | - |
dc.contributor.googleauthor | Ta-Chuan Yeh | - |
dc.contributor.googleauthor | Szu-Nian Yang | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Che-Sheng Chu | - |
dc.contributor.googleauthor | Ping-Tao Tseng | - |
dc.contributor.googleauthor | Kuan-Pin Su | - |
dc.identifier.doi | 10.3390/jcm11040938 | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 35207210 | - |
dc.subject.keyword | depression | - |
dc.subject.keyword | meta-analysis | - |
dc.subject.keyword | psilocybin | - |
dc.subject.keyword | psychedelics | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 938 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.11(4) : 938, 2022-02 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.