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Clinical impact of antineutrophil cytoplasmic antibody positivity on the occurrence of interstitial lung disease in patients with polymyositis/dermatomyositis
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 송정식 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 표정윤 | - |
dc.contributor.author | 하장우 | - |
dc.date.accessioned | 2023-03-03T02:06:04Z | - |
dc.date.available | 2023-03-03T02:06:04Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 2224-5820 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192737 | - |
dc.description.abstract | Background: This study investigated the clinical impact of antineutrophil cytoplasmic antibody (ANCA) positivity on the occurrence of interstitial lung disease (ILD) in patients with probable and definite polymyositis (PM)/dermatomyositis (DM) who met both the Bohan and Peter and the 2017 European League Against Rheumatism/American College of Rheumatology criteria. Methods: The medical records of 75 PM/DM patients were retrospectively reviewed. ANCA and anti-Jo 1 positivity at diagnosis were obtained, and pulmonary function test and chest high-resolution computed tomography results at ILD occurrence were collected. The follow-up duration based on ILD was defined as the period from the time of PM/DM diagnosis to the occurrence of ILD in PM/DM patients with ILD and to the last visit for those without ILD. Results: The median age was 50.0 years and 21.3% were male. ANCA and anti-Jo 1 were detected in 12 (16.0%) and 26 patients (34.7%), respectively. ILD occurred in 32 patients, 24 of whom had ILD at the time of PM/DM diagnosis. Anti-Jo 1 was detected more often in PM/DM patients without ANCA than those with (39.7% vs. 8.3%). ILD occurred more frequently in PM/DM patients with ANCA than those without ANCA (75.0% vs. 36.5%). However, the occurrence of ILD was not affected by anti-Jo 1 positivity. Furthermore, ANCA-positive PM/DM patients exhibited a significantly lower cumulative ILD-free survival rate than ANCA-negative PM/DM patients (P=0.009). Conclusions: ANCA positivity at the time of PM/DM diagnosis might be an important risk factor for ILD in PM/DM patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | AME Publishing Company | - |
dc.relation.isPartOf | ANNALS OF PALLIATIVE MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antibodies, Antineutrophil Cytoplasmic | - |
dc.subject.MESH | Dermatomyositis* / complications | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Diseases, Interstitial* / complications | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymyositis* / complications | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Clinical impact of antineutrophil cytoplasmic antibody positivity on the occurrence of interstitial lung disease in patients with polymyositis/dermatomyositis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jang Woo Ha | - |
dc.contributor.googleauthor | Jung Yoon Pyo | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Jason Jungsik Song | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.identifier.doi | 10.21037/apm-22-604 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A04244 | - |
dc.contributor.localId | A06125 | - |
dc.relation.journalcode | J04374 | - |
dc.identifier.eissn | 2224-5839 | - |
dc.identifier.pmid | 36226644 | - |
dc.subject.keyword | Antineutrophil cytoplasmic antibody (ANCA) | - |
dc.subject.keyword | dermatomyositis | - |
dc.subject.keyword | interstitial lung disease (ILD) | - |
dc.subject.keyword | polymyositis | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 송정식 | - |
dc.contributor.affiliatedAuthor | 안성수 | - |
dc.contributor.affiliatedAuthor | 이상원 | - |
dc.contributor.affiliatedAuthor | 표정윤 | - |
dc.contributor.affiliatedAuthor | 하장우 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 3181 | - |
dc.citation.endPage | 3192 | - |
dc.identifier.bibliographicCitation | ANNALS OF PALLIATIVE MEDICINE, Vol.11(10) : 3181-3192, 2022-10 | - |
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