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Asian-specific 3'UTR variant in CDKN2B associated with risk of pituitary adenoma

DC Field Value Language
dc.contributor.author김선호-
dc.contributor.author김세훈-
dc.contributor.author김의현-
dc.contributor.author장종희-
dc.contributor.author윤선진-
dc.date.accessioned2022-12-22T05:12:26Z-
dc.date.available2022-12-22T05:12:26Z-
dc.date.issued2022-11-
dc.identifier.issn0301-4851-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/192331-
dc.description.abstractBackground: Previous genomewide association studies (GWASs), single nucleotide polymorphisms (SNPs) on cyclin-dependent kinase inhibitor 2 A (CDKN2A), cyclin-dependent kinase inhibitor 2B (CDKN2B), and cyclin-dependent kinase inhibitor 2B antisense RNA1 (CDKN2B-AS1) were reported as risk loci for glioma, a subgroup of the brain tumor. To further characterize this association with the risk of brain tumors in a Korean population, we performed a fine-mapping association study of CDKN2A, CDKN2B, and CDKN2B-AS1. Methods and results: A total of 17 SNPs were selected and genotyped in 1,439 subjects which were comprised of 959 patients (pituitary adenoma 335; glioma 324; meningioma 300) and 480 population controls (PCs). We discovered that a 3'untranslated region (3'UTR) variant, rs181031884 of CDKN2B (Asian-specific variant), had significant association with the risk of pituitary adenoma (PA) (Odds ratio = 0.58, P = 0.00003). Also, rs181031884 appeared as an independent causal variant among the significant variants in CDKN2A and CDKN2B, and showed dose-dependent effects on PA. Conclusions: Although further studies are needed to verify the impact of this variant on PA susceptibility, our results may help to understand CDKN2B polymorphism and the risk of PA.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherReidel-
dc.relation.isPartOfMOLECULAR BIOLOGY REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESH3' Untranslated Regions / genetics-
dc.subject.MESHCyclin-Dependent Kinase Inhibitor p15 / genetics-
dc.subject.MESHCyclin-Dependent Kinase Inhibitor p16 / genetics-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHGlioma*-
dc.subject.MESHHumans-
dc.subject.MESHPituitary Neoplasms* / genetics-
dc.subject.MESHPolymorphism, Single Nucleotide / genetics-
dc.subject.MESHRNA, Long Noncoding* / genetics-
dc.titleAsian-specific 3'UTR variant in CDKN2B associated with risk of pituitary adenoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorByeong Ju Youn-
dc.contributor.googleauthorHyun Sub Cheong-
dc.contributor.googleauthorSuhg Namgoong-
dc.contributor.googleauthorLyoung Hyo Kim-
dc.contributor.googleauthorIn Ki Baek-
dc.contributor.googleauthorJeong-Hyun Kim-
dc.contributor.googleauthorSeon-Jin Yoon-
dc.contributor.googleauthorEui Hyun Kim-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorSun Ho Kim-
dc.contributor.googleauthorHyoung Doo Shin-
dc.identifier.doi10.1007/s11033-022-07796-1-
dc.contributor.localIdA00560-
dc.contributor.localIdA00610-
dc.contributor.localIdA00837-
dc.contributor.localIdA03470-
dc.relation.journalcodeJ02249-
dc.identifier.eissn1573-4978-
dc.identifier.pmid36097105-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s11033-022-07796-1-
dc.subject.keywordCyclin-dependent kinase inhibitor 2B (CDKN2B)-
dc.subject.keywordKorean population-
dc.subject.keywordPituitary adenoma (PA)-
dc.subject.keywordSingle nucleotide polymorphism (SNP)-
dc.contributor.alternativeNameKim, Sun Ho-
dc.contributor.affiliatedAuthor김선호-
dc.contributor.affiliatedAuthor김세훈-
dc.contributor.affiliatedAuthor김의현-
dc.contributor.affiliatedAuthor장종희-
dc.citation.volume49-
dc.citation.number11-
dc.citation.startPage10339-
dc.citation.endPage10346-
dc.identifier.bibliographicCitationMOLECULAR BIOLOGY REPORTS, Vol.49(11) : 10339-10346, 2022-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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