Cited 0 times in
Prognostic Impact of MAFLD Following Surgical Resection of Hepatitis B Virus-Related Hepatocellular Carcinoma: A Nationwide Cohort Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김범경 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 윤진하 | - |
dc.contributor.author | 윤병윤 | - |
dc.date.accessioned | 2022-12-22T04:37:38Z | - |
dc.date.available | 2022-12-22T04:37:38Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192179 | - |
dc.description.abstract | The association between the metabolic effects of hepatic steatosis as a part of postoperative outcomes of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) has rarely been studied. This study aimed to assess the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and patients' prognoses following curative resection of HBV-related HCC. Patients who underwent surgical resection for HBV-related HCC between 2009 and 2015 were recruited. The study endpoints were postoperative hepatocellular carcinoma (HCC) recurrence and all-cause mortality. Adjusted hazard ratios (aHRs) for the outcomes were estimated using multivariate Cox regression models. The mean age of the 2032 enrolled patients was 55.0 years, and 77.9% were men. During follow-up (median 5.3 years), HCC recurrence and all-cause mortality occurred in 954 (47.0%) and 422 (20.8%) patients, respectively. HCC recurrence and all-cause mortality were significantly associated with MAFLD, with aHRs of 1.22 (p = 0.003) and 1.44 (p < 0.001), respectively. Propensity score matching and inverse probability treatment weighting analyses confirmed similar results (p < 0.05). MAFLD was associated with significantly poor prognoses in terms of HCC recurrence and all-cause mortality following surgical resection of HBV-related HCC. Further studies are needed to develop an effective preventive strategy through the management of metabolic health. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Prognostic Impact of MAFLD Following Surgical Resection of Hepatitis B Virus-Related Hepatocellular Carcinoma: A Nationwide Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Byungyoon Yun | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Juyeon Oh | - |
dc.contributor.googleauthor | Jin-Ha Yoon | - |
dc.contributor.googleauthor | Beom Kyung Kim | - |
dc.identifier.doi | 10.3390/ cancers14205002 | - |
dc.contributor.localId | A00487 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A04616 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 36291786 | - |
dc.subject.keyword | MAFLD | - |
dc.subject.keyword | hepatitis B virus | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | surgery | - |
dc.contributor.alternativeName | Kim, Beom Kyung | - |
dc.contributor.affiliatedAuthor | 김범경 | - |
dc.contributor.affiliatedAuthor | 안상훈 | - |
dc.contributor.affiliatedAuthor | 윤진하 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 5002 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.14(20) : 5002, 2022-10 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.