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Prognostic Impact of MAFLD Following Surgical Resection of Hepatitis B Virus-Related Hepatocellular Carcinoma: A Nationwide Cohort Study

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dc.contributor.author김범경-
dc.contributor.author안상훈-
dc.contributor.author윤진하-
dc.contributor.author윤병윤-
dc.date.accessioned2022-12-22T04:37:38Z-
dc.date.available2022-12-22T04:37:38Z-
dc.date.issued2022-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/192179-
dc.description.abstractThe association between the metabolic effects of hepatic steatosis as a part of postoperative outcomes of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) has rarely been studied. This study aimed to assess the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and patients' prognoses following curative resection of HBV-related HCC. Patients who underwent surgical resection for HBV-related HCC between 2009 and 2015 were recruited. The study endpoints were postoperative hepatocellular carcinoma (HCC) recurrence and all-cause mortality. Adjusted hazard ratios (aHRs) for the outcomes were estimated using multivariate Cox regression models. The mean age of the 2032 enrolled patients was 55.0 years, and 77.9% were men. During follow-up (median 5.3 years), HCC recurrence and all-cause mortality occurred in 954 (47.0%) and 422 (20.8%) patients, respectively. HCC recurrence and all-cause mortality were significantly associated with MAFLD, with aHRs of 1.22 (p = 0.003) and 1.44 (p < 0.001), respectively. Propensity score matching and inverse probability treatment weighting analyses confirmed similar results (p < 0.05). MAFLD was associated with significantly poor prognoses in terms of HCC recurrence and all-cause mortality following surgical resection of HBV-related HCC. Further studies are needed to develop an effective preventive strategy through the management of metabolic health.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePrognostic Impact of MAFLD Following Surgical Resection of Hepatitis B Virus-Related Hepatocellular Carcinoma: A Nationwide Cohort Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorByungyoon Yun-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorJuyeon Oh-
dc.contributor.googleauthorJin-Ha Yoon-
dc.contributor.googleauthorBeom Kyung Kim-
dc.identifier.doi10.3390/ cancers14205002-
dc.contributor.localIdA00487-
dc.contributor.localIdA02226-
dc.contributor.localIdA04616-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid36291786-
dc.subject.keywordMAFLD-
dc.subject.keywordhepatitis B virus-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordprognosis-
dc.subject.keywordsurgery-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.affiliatedAuthor김범경-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor윤진하-
dc.citation.volume14-
dc.citation.number20-
dc.citation.startPage5002-
dc.identifier.bibliographicCitationCANCERS, Vol.14(20) : 5002, 2022-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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